ID G1L638_AILME Unreviewed; 904 AA.
AC G1L638;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=MDM2 binding protein {ECO:0000313|Ensembl:ENSAMEP00000002352.2};
GN Name=MTBP {ECO:0000313|Ensembl:ENSAMEP00000002352.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002352.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000002352.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000002352.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1L638; -.
DR STRING; 9646.ENSAMEP00000002352; -.
DR Ensembl; ENSAMET00000002451.2; ENSAMEP00000002352.2; ENSAMEG00000002231.2.
DR eggNOG; ENOG502RGBH; Eukaryota.
DR GeneTree; ENSGT00390000003305; -.
DR HOGENOM; CLU_017071_0_0_1; -.
DR InParanoid; G1L638; -.
DR OrthoDB; 5349610at2759; -.
DR TreeFam; TF331503; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:Ensembl.
DR GO; GO:0031396; P:regulation of protein ubiquitination; IEA:InterPro.
DR GO; GO:0007089; P:traversing start control point of mitotic cell cycle; IEA:Ensembl.
DR InterPro; IPR039061; MTBP.
DR InterPro; IPR029418; MTBP_C.
DR InterPro; IPR029420; MTBP_central.
DR InterPro; IPR029421; MTBP_N.
DR PANTHER; PTHR14382; MDM2-BINDING PROTEIN; 1.
DR PANTHER; PTHR14382:SF1; MDM2-BINDING PROTEIN; 1.
DR Pfam; PF14920; MTBP_C; 1.
DR Pfam; PF14919; MTBP_mid; 1.
DR Pfam; PF14918; MTBP_N; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1..268
FT /note="DM2"
FT /evidence="ECO:0000259|Pfam:PF14918"
FT DOMAIN 293..632
FT /note="DM2"
FT /evidence="ECO:0000259|Pfam:PF14919"
FT DOMAIN 636..894
FT /note="MDN2-binding protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14920"
FT REGION 18..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 100998 MW; 1CD9594C00B7AC16 CRC64;
MDRYLLLVIW GEGKVPSAAA EETEHGPGES SAEGTEKLPD LTAANVYHLL KRSISASVNP
EDSTFPACSV GGIPGSKKWF FAVQAICGFY QFCSSDWEEI HFGTEKDEIE DVLQTNIEEC
LSAECFEEED SNSRESLSLA DLYEESAENL QQLSDKLPAP GRAMIDIILL PSDKDPPKLK
DCLPAVGALK HLKEWYSAKI TIAGSHYEIN CQKIAEYLSA NVVSLEDLKN AIDSKELWRG
KIQIWERKFG FEISFPEFCL KGVTPKNFST SNLNPCLLAK KVISSKDKNI LPKVFHYYGP
ALEFVQMIKL SDLPSCYMSD IEFELGLTKN NTKQNSMLLL EQISSLHGKV GALFVLPCTI
SNILIPPPSQ LSSKKWREYI AKKPKTISVP DVEVKGECSS YYLLLQGNGN RKCKATLIHS
ANQINGSFAL SLIHGKMKAR TEEADLSFPF DFLSLPHFSG EQLIQREKQL ANVQALALKE
CLKRRKLAKQ PEVVSVDELK SLLILIRERF LDRFDALIPK TVPIKTDKIK TSNMLNGTSS
VEPTSSNLME TNPLEWPERH VLQNLESFEK AKQKMRTGSL PRSSEQLLGH KEGPRDSNTL
LDAKELLKFF TSDGLPIGDL QPLQIQKGEK TFVLTPELSP GKLQGLPFEK ASVCHYHGIE
YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT VLSPLPSPAV LSEPGSVPDG
EALQSELRTE VSRLKRRSKD LNGLYPQKRL VKSESSDSLL SQTSGSTNHH PDAVTSRKPR
AERSFSVACP SLPVLSHETP KVTTKASSGQ KSVHGSKMSR QIKESRSQKH TRILKEVVTE
TLKKHSITEA HGCFTACSHR LFEISKLYLK DLKTSRGLFE EMKKAANNNA VQVIEWVLEK
TSKK
//
