ID G1L8H9_AILME Unreviewed; 1098 AA.
AC G1L8H9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Sodium/potassium/calcium exchanger 1 {ECO:0000256|ARBA:ARBA00040585};
DE AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 1 {ECO:0000256|ARBA:ARBA00042035};
DE AltName: Full=Retinal rod Na-Ca+K exchanger {ECO:0000256|ARBA:ARBA00042297};
DE AltName: Full=Solute carrier family 24 member 1 {ECO:0000256|ARBA:ARBA00042684};
GN Name=SLC24A1 {ECO:0000313|Ensembl:ENSAMEP00000003196.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000003196.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000003196.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000003196.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR AlphaFoldDB; G1L8H9; -.
DR STRING; 9646.ENSAMEP00000003196; -.
DR Ensembl; ENSAMET00000003327.2; ENSAMEP00000003196.2; ENSAMEG00000003029.2.
DR eggNOG; KOG1307; Eukaryota.
DR GeneTree; ENSGT01030000234532; -.
DR HOGENOM; CLU_007948_6_0_1; -.
DR InParanoid; G1L8H9; -.
DR TreeFam; TF318759; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR004817; SLC24A1.
DR NCBIfam; TIGR00927; 2A1904; 1.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF36; SODIUM_POTASSIUM_CALCIUM EXCHANGER 1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 936..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1035..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..603
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 937..1085
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 99..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..896
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 120028 MW; 6EC08FB21060C0A3 CRC64;
MGKLIRMGTW ERRLLRPKRL RWSRLLFLLG MLIIGSTYQH LRSPRGLPSL WAAVSSQHPV
KLASRDLPND DMMMVRSDPP RASSEMAGDT LVSQATVGRD EAAPGIAMEN TPNPPRRTAN
TTPTIPKNNY SLTAADTERM KEDTTTTPSR VLNHYTPTSS RPTVKNHTPT TPPGREKQSY
HPTEAGGKVK KYTPSPLVRL VGNYAPSTLT TMTKSHGITP RTTLKDSETM TTTKILEANP
SKRIVEETPP TTVKGIIHKT PTSLIHDIET NILTSPRSMT EKNTLTTPRR ADNNRSTKPW
GLVGKNELTT PLGTVLEHTT AISEGQVTIH STTGSGPTET KASTAWTIRN PLSRTSALTF
GVSSTTFRGL AKKPSTAPST SPTSEVRANP TIQVHHCVVV EPAPAVPPAP SPSLTRATIL
EASSSSPSAL PPGWPDLHSK AEYPPDLFSI EERRQGWVVL HIFGMMYVFV ALAIVCDEYF
VPALGVITDK LQISDDVAGA TFMAAGGSAP ELFTSLIGVF ISHSNVGIGT IVGSAVFNIL
FVIGTCALFS REILNLTWWP LFRDVSFYIL DLIMLILFFL DSLIAWWESL LLLLAYAFYV
FTMKWNKWLE VWVKEQLSRR PVAKVMALGD LSKCVFLGEC VFREGQTLVL PAVLTRGSSS
ASLHNSTIRS TIYQLMLHSL DPLGEARPSK DKEEEESLSQ EAKAKPHANA ENEPEEEEPA
ELPAVTASPA PAPDVKGDRE KDPSSQEGDV AGAESTGEVI GEEAEAPGRG ENGPQGGGET
QLEGEGEIEA EGAGEPEGDM KVEEGEGEHE ERKVTDEGGG ELQAEDGETK ADEGENEEQE
LNAESQGEAK SDEKGRDGDG GGEGGGSEDE EEEEDEEEEE EEDEEEEEEE ANEEPLSLEW
PESRQKQAIY LFLLPIVFPL WLTVPDVRRL ESKKFFVFTF LGSIVWIAMF SYLMVWWAHQ
VGETVGISEE IMGLTILAAG TSIPDLITSV IVARKGLGDM AVSSSVGSNI FDITVGLPVP
WLLFSLINGL QPVPVSSNGL FCAIVLLFLM LLFVISSIAS CKWRMNKILG FTMFLLYFVF
LIISVMLEDR IISCPVSV
//
