ID G1LCN1_AILME Unreviewed; 1090 AA.
AC G1LCN1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=MLLT6, PHD finger containing {ECO:0000313|Ensembl:ENSAMEP00000004661.2};
GN Name=MLLT6 {ECO:0000313|Ensembl:ENSAMEP00000004661.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000004661.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000004661.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000004661.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1LCN1; -.
DR STRING; 9646.ENSAMEP00000004661; -.
DR Ensembl; ENSAMET00000004850.2; ENSAMEP00000004661.2; ENSAMEG00000004398.2.
DR eggNOG; KOG0956; Eukaryota.
DR GeneTree; ENSGT00940000158572; -.
DR HOGENOM; CLU_010286_1_0_1; -.
DR InParanoid; G1LCN1; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0006325; P:chromatin organization; IEA:Ensembl.
DR GO; GO:0035811; P:negative regulation of urine volume; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0036359; P:renal potassium excretion; IEA:Ensembl.
DR GO; GO:0035812; P:renal sodium excretion; IEA:Ensembl.
DR GO; GO:0070295; P:renal water absorption; IEA:Ensembl.
DR CDD; cd15709; ePHD_AF17; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF90; PROTEIN AF-17; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..57
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 62..181
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 117..180
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 188..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..752
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 225..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..863
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 111760 MW; E25EEBBF788FD310 CRC64;
MKEMVGGCCV CSDERGWAEN PLVYCDGHAC SVAVHQACYG IVQVPTGPWF CRKCESQERA
ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV LTMEPIVLQY VPHDRFNKTC
YICEEQGRES KAASGACMTC NRHGCRQAFH VTCAQMAGLL CEEEVLEVDN VKYCGYCKYH
FSKMKTSRHT SGGGGGAGGS STGGGGSGFI AGRRSRSASP STQQEKHPSH HERGQKKSRK
DKERLKQKHK KRPESPPSIL TPPVVSTADK VPSSASSSSH HEASTQETSE SSRDLKGKKS
SSHSLSHKGK KLSSGKGVSS FTSASSSASS SSSSSGGPFQ PAVSSLQSSP DFSAFPKLEQ
PEEDKYSKPA APTPSAPPSP SAPEPPKADL FEQKVVFSGF GPIMRFSTTT SSSGRARAPS
PGDYKSPHVS GSGASAGTHK RMPTLSAAPA PAEETPETGL KEKKHKASKR SRHGPGRPKG
SRNKEGAGGP AAPSLPSAQL AGFTATAASP FSGGSLVSSG LGGLASRTFG PSGSLPSLSL
ESPLLGAGIY TSNKDPISHG GSGGMLRAVC STPLSSSLLG PPGTSALPRL SRSPFTSTLP
SSSASISTTQ VFSLAGSTFS LPSTHIFGTP MGAVNPLLTQ AESSHTEPDL EDCSFRCRGT
SPQESLSSMS PISSLPALFD QTASAPCGGG QLDPAAPGTT NMEQLLEKQG DGEAGVNIVE
MLKALHALQK ENQRLQEQIL SLTAKKERLQ ILNVQLSVPF PALPAALPAA NGPVPGPYGL
PPQAGSSDSL STSKSPPGKN SLGLDNSLST SSEDPHSGCP SRSSSSLSFH STPPPLPLLQ
QSPATLPLAL PGAPAPLPPQ PQNGLGRAPG AAGLGAMPMA EGLLGGLAGS GALPLNGLLG
GLNGAAAPNP AGLSQAGGAP TLQLPGCLNS LTEQQRHLLQ QQEQQLQQLQ QLLASPQLTP
EHQTVVYQMI QQIQQKRELQ RLQLAGGSQL PMAGLLAGSS TPLLSAGTPG LLPTASAPPL
LPAGALVAPS LGNNTSLMAA AAAAAAVAAA GGPPVLTAQT NPFLSLAGAD GSGPKGGTAD
KGTSANQEKG
//
