GenomeNet

Database: UniProt
Entry: G1LCQ9_AILME
LinkDB: G1LCQ9_AILME
Original site: G1LCQ9_AILME 
ID   G1LCQ9_AILME            Unreviewed;      2363 AA.
AC   G1LCQ9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN   Name=SPTBN1 {ECO:0000313|Ensembl:ENSAMEP00000004689.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000004689.1, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000004689.1, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000004689.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR   RefSeq; XP_002914092.1; XM_002914046.3.
DR   STRING; 9646.ENSAMEP00000004689; -.
DR   Ensembl; ENSAMET00000004879.2; ENSAMEP00000004689.1; ENSAMEG00000004191.2.
DR   GeneID; 100477448; -.
DR   KEGG; aml:100477448; -.
DR   CTD; 6711; -.
DR   eggNOG; KOG0517; Eukaryota.
DR   GeneTree; ENSGT00940000154864; -.
DR   HOGENOM; CLU_000146_1_2_1; -.
DR   InParanoid; G1LCQ9; -.
DR   OMA; EMPSAQM; -.
DR   OrthoDB; 2872403at2759; -.
DR   TreeFam; TF313446; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0030673; C:axolemma; IEA:Ensembl.
DR   GO; GO:0032437; C:cuticular plate; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0031430; C:M band; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0008091; C:spectrin; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR   GO; GO:0021556; P:central nervous system formation; IEA:Ensembl.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Ensembl.
DR   GO; GO:0071709; P:membrane assembly; IEA:Ensembl.
DR   GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR   GO; GO:0007009; P:plasma membrane organization; IEA:Ensembl.
DR   GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR   GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0060390; P:regulation of SMAD protein signal transduction; IEA:Ensembl.
DR   CDD; cd21248; CH_SPTB_like_rpt2; 1.
DR   CDD; cd21316; CH_SPTBN1_rpt1; 1.
DR   CDD; cd10571; PH_beta_spectrin; 1.
DR   CDD; cd00176; SPEC; 8.
DR   Gene3D; 1.20.58.60; -; 12.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001605; PH_dom-spectrin-type.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR016343; Spectrin_bsu.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF226; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 1; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF00435; Spectrin; 17.
DR   PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00150; SPEC; 17.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 15.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW   ECO:0000256|PIRNR:PIRNR002297};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW   ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR002297};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          54..158
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          173..278
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          2196..2306
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          2088..2195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2308..2363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          457..491
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          990..1031
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1096..1123
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1421..1455
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1852..1879
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2088..2104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2105..2177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2308..2339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2340..2356
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2363 AA;  274344 MW;  C1ADC64FB60F1846 CRC64;
     MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD EREAVQKKTF
     TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL
     QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI WTIILRFQIQ DISVETEDNK EKKSAKDALL
     LWCQMKTAGY PNVNIHNFTT SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL
     AEQHLGLTKL LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
     EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV EKPPKFTEKG
     NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE KAEHERELAL RNELIRQEKL
     EQLARRFDRK AAMRETWLSE NQRLVSQDNF GFDLPAVEAA TKKHEAIETD IAAYEERVQA
     VVAVARELEA ENYHDIKRIT ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI
     MDWMDEMKVL LLSQDYGKHL LGVEDLLQKH ALVEADIGIQ AERVRGVNAS AQKFATDGEG
     YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE EGWIREKEKI
     LSSDDYGKDL TSVVRLLSKH RAFEDEMSGR SGHFEQAIKE GEDMIAEEHF GSEKIRERIL
     YIREQWANLE QLSAIRKKRL EEASLLHQFQ ADADDIDAWM LDVLRIASSN DVGHDEYSTQ
     SLVKKHKDVA EEIANYRPTI DSLHEQAGAL PQEHAESPDV RGRLSGIEER YKEVAELTRL
     RKQALQDTLA LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
     QASRVAVVNQ IARQLMHSGH PSEKIKAQQD KLNTRWSQFR ELVDRKKDAL LSALSIQNYH
     LECNETKSWI REKTKVIEST QDLGNDLAGV MALQRKLTGM ERDLVAIEAK LSDLQKEAEK
     LESEHPDQAQ AILSRLAEIS DVWEEMKTTL KNREASLGEA SKLQQFLRDL DDFQSWLSRT
     QTAIASEDMP NTLTEAEKLL TQHENIKNEI DNYEEDYQKM RDMGEMVTQG QTDAQYMFLR
     QRLQALDTGW NELHKMWENR QNLLSQSHAY QQFLRDTKQA EAFLNNQEYV LAHTEMPTTL
     EGAEAAIKKQ EDFMTTMDAN EEKINAVVET GRRLVSDGNI NSDRIQEKVD SIDDRHRKNR
     EAASELLMRL KDNRDLQKFL QDCQELSLWI NEKMLTAQDM SYDEARNLHS KWLKHQAFMA
     ELASNKEWLD KIEKEGMQLI SEKPETEAVV KEKLTGLHNM WEVLESTTQT KAQRLFDANK
     AELFTQSCAD LDKWLHGLES QIQSDDYGKD LTSVNILLKK QQMLENQMEV RKKEIEELQS
     QAQALSQEGK STDEVDSKRL TVQTKFMELL EPLNERKHNL LASKEIHQFN RDVEDEILWV
     GERMPLATST DHGHNLQTVQ LLIKKNQTLQ KEIQGHQPRI DDIFERSQSI VTDSSSLNAE
     AIRRRLADLK ELWGLLIEET EKRHRRLEEA HRAQQYYFDA AEAEAWMSEQ ELYMMSEEKA
     KDEQSAVSML KKHQILEQAV EDYAETVHQL SKTSRALVAD SHPESERISM RQSKVDKLYA
     GLKDLAEERR GKLDERHRLF QLNREVDDLE QWIAEREVVA GSHELGQDYE HVTMLQERFR
     EFARDTGNIG QERVDTVNHM ADELINSGHS DAATIAEWKD GLNEAWADLL ELIDTRTQIL
     AASYELHKFY HDAKEIFGRI QDKHKKLPEE LGRDQNTVET LQRMHTTFEH DIQALGTQVR
     QLQEDAARLQ AAYAGDKADD IQKRENEVLE AWKALLDACE GRRVRLVDTG DKFRFFSMVR
     DLMLWMEDVI RQIEAQEKPR DVSSVELLMN NHQGIKAEID ARNDSFTTCI ELGKSLLARK
     HYASEEIKEK LLQLTEKRKE MIDKWEDRWE WLRLILEVHQ FSRDASVAEA WLLGQEPYLS
     SREIGQSVDE VEKLIKRHEA FEKSAATWDE RFSALERLTT LELLEVRRQQ EEEERKRRPP
     SPEPSTKASE ETESQQQWDT SKGEQVSQNG LPAEQGSPRM AETVDTSEMV NGAAEQRTSS
     KESSPIPSPT SDRKAKTALP AQSAATLPAR TQETPSAQME GFLNRKHEWE AHNKKASSRS
     WHNVYCVINN QEMGFYKDAK TAASGIPYHS EVPVSLKEAI CEVALDYKKK KHVFKLRLND
     GNEYLFQAKD DEEMNTWIQA ISSAISSDKH EVSASTQSTP ASSRAQTLPT SVVTITSESS
     PGKREKDKEK DKEKRFSIFG KKK
//
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