ID G1LEB3_AILME Unreviewed; 563 AA.
AC G1LEB3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Transmembrane protein 145 {ECO:0000313|Ensembl:ENSAMEP00000005247.2};
GN Name=TMEM145 {ECO:0000313|Ensembl:ENSAMEP00000005247.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005247.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005247.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005247.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G1LEB3; -.
DR STRING; 9646.ENSAMEP00000005247; -.
DR Ensembl; ENSAMET00000005463.2; ENSAMEP00000005247.2; ENSAMEG00000004959.2.
DR eggNOG; KOG4290; Eukaryota.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_021549_3_0_1; -.
DR InParanoid; G1LEB3; -.
DR TreeFam; TF314975; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170760"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..411
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 563 AA; 62681 MW; 526A1BCE459184C9 CRC64;
MEPPRAPALC RLLPPLLLLL LPLSPRARAK YVRGNLSSKE DWLFLTRFCF LSDYGRLDFR
FRYPEAKCCQ NILLYFDDLS QWPAVYKAGD KDCLAKESVV RPENNQVINL TTQYAWSGCQ
VASEEGTRYL SCSSGRSFRS VRERWWYIAL SKCGGDGLQL EYEMVLTNGK SFWTRHFSAD
EFGILETDVT FLLIFILIFF LSCYFGYLLK GRQLLHTTYK MFMAAAGVEV LSLLFFCIYW
GQYATDGIGN ESLKILAKLL FSSSFLIFLL MLILLGKGFT VTRGRISHSG SVKLSVYMTL
YTLTHVALLI YEAEFFDPGQ VLYTYESPAG YGLIGLQVAA YVWFCYAVLI SLRHFPEKQP
FYVPFFAAYT LWFFAVPVMA LIANFGIPKW AREKIVNGIQ LGIHLYAHGV FLIMTRPSAA
NKNFPYHVRT SQIASAGASG PGGSQSTGKA FPQHVYGNVT FISDSVPNFT ELFSIPPPAS
SAGKQVEETA VAAAVAPRGR VVTMAEPGVA SPPLTARFPK AADPSWDGPT PPYQPLVPQT
AAPHTGFTEY FSMHTAGGTA PPV
//
