ID G1LFK8_AILME Unreviewed; 2821 AA.
AC G1LFK8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSAMEP00000005696.2};
GN Name=NF1 {ECO:0000313|Ensembl:ENSAMEP00000005696.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005696.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005696.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005696.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9646.ENSAMEP00000005696; -.
DR Ensembl; ENSAMET00000005935.2; ENSAMEP00000005696.2; ENSAMEG00000005313.2.
DR eggNOG; KOG1826; Eukaryota.
DR GeneTree; ENSGT00550000074797; -.
DR HOGENOM; CLU_000249_0_0_1; -.
DR InParanoid; G1LFK8; -.
DR TreeFam; TF300302; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0021764; P:amygdala development; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0021897; P:forebrain astrocyte development; IEA:Ensembl.
DR GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR GO; GO:0061534; P:gamma-aminobutyric acid secretion, neurotransmission; IEA:Ensembl.
DR GO; GO:0061535; P:glutamate secretion, neurotransmission; IEA:Ensembl.
DR GO; GO:0048820; P:hair follicle maturation; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0033024; P:mast cell apoptotic process; IEA:Ensembl.
DR GO; GO:0070662; P:mast cell proliferation; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR GO; GO:0097529; P:myeloid leukocyte migration; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0002686; P:negative regulation of leukocyte migration; IEA:Ensembl.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0070667; P:negative regulation of mast cell proliferation; IEA:Ensembl.
DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0035021; P:negative regulation of Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:1900148; P:negative regulation of Schwann cell migration; IEA:Ensembl.
DR GO; GO:0010626; P:negative regulation of Schwann cell proliferation; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0021915; P:neural tube development; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0098597; P:observational learning; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0033027; P:positive regulation of mast cell apoptotic process; IEA:Ensembl.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0045124; P:regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:1900271; P:regulation of long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0036135; P:Schwann cell migration; IEA:Ensembl.
DR GO; GO:0014010; P:Schwann cell proliferation; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
DR GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR GO; GO:1904738; P:vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:1990874; P:vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1218..1434
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1563..1721
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2782..2821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2785..2813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2821 AA; 317256 MW; 3E8286102623D5DB CRC64;
QLPIKTGQQN THTKVSTEHN KECLINISKY KFSLVISGLT TILKNVNNMR IFGEAAEKNL
YLSQLIILDT LEKCLAGQPK DTMRLDETML VKQLLPEICH FLHTCREGNQ HAAELRNSAS
GVLFSLSCNN FNAVFSRIST RLQELTVCSE DNVDVHDIEL LQYINVDCAK LKRLLKETAF
KFKALKKVAQ LAVINSLEKA FWNWVENYPD EFTKLYQIPQ TDMAECAEKL FDLVDGFAES
TKRKAAVWPL QIILLILCPE IIQDISKDVV DENNMNKKLF LDSLRKALAG HGGSRQLTES
AAIACVKLCK ASTYINWEDN SVIFLLVQSM VVDLKNLLFN PSKPFSRGSQ PADVDLMIDC
LVSCFRISPH NNQHFKICLA QNSPSTFHYV LVNSLHRIIT NSALDWWPKI DAVYCHSVEL
RNMFGETLHK AVQGCGAHPA IRMAPSLTFK EKVTSLKFKE KPTDLETRSY KYLLLSMVKL
IHADPKLLLC NPRKQGPETQ GSTAELITGL VQLVPQSHMP EIAQEAMEAL LVLHQLDSID
LWNPDAPVET FWEISSQMLF YICKKLTSHQ MLSSTEILKW LREILICRNK YLLKNKQADR
SSCHFLFLYG VGCDVPSSGT TGQMSMNHEE LLPSCTPGAS LRKGKGNSSM DSAAGCSGTP
PICRQAQTKL EVALYMFLWS PDTEAVLVAM SCFRHLCEEA DIRCGVDEVS VHNFLPNYNT
FMEFASVSNM MSTGRAALQK RVMALLRRIE HPTAGNTEAW EDTHAKWEQA TKLILNYPKA
KMEDGQAAES LHKTIVKRRM SHVSGGGSID LSDTDSLQEW INMTGFLCAL GGVCLQQRSN
SGLATYSPPM GPVSERKGSM ISVMSSEGNA DTPVSKFMDR LLSLMVCNHE KVGLQIRTNV
KDLVGLELSP ALYPMLFNKL KNTISKFFDS QGQVLLTDTN TQFVEQTIAI MKNLLDNHTE
GSSEHLGQAS IETMMLNLVR YVRVLGNMVH AIQIKTKLCQ LVEVMMARRD DLSFCQEMKF
RNKMVEYLTD WVMGTSNQAA DDDVKCLTRD LDQASMEAVV SLLAGLPLQP EEGDGVELME
AKSQLFLKYF TLFMNLLNDC SEVEDENAQT GGRKRGMSRR LASLRHCTVL AMSNLLNANV
DSGLMHSIGL GYHKDLQTRA TFMEVLTKIL QQGTEFDTLA ETVLADRFER LVELVTMMGD
QGELPIAMAL ANVVPCSQWD ELARVLVTLF DSRHLLYQLL WNMFSKEVEL ADSMQTLFRG
NSLASKIMTF CFKVYGATYL QKLLDPLLRI VITSSDWQHV SFEVDPTRLE QSESLEENQR
NLLQMTEKFF HAIISSSSEF PPQLRSVCHC LYQATCHSLL NKATVKEKKE NKKSVVSQRF
PQNSIGAVGS AMFLRFINPA IVSPYEAGIL DKKPPPRIER GLKLMSKILQ SIANHVLFTK
EEHMRPFNDF VKSNFDAARR FFLDIASDCP TSDAVNHSLS FISDGNVLAL HRLLWNNQEK
IGQYLSSNRD HKAVGRRPFD KMATLLAYLG PPEHKPVADT HWSSLNLTSS KFEEFMTRHQ
VHEKEEFKAL KTLSIFYQAG TSKAGNPIFY YVARRFKTGQ INGDLLIYHV LLTLKPYYAK
PYEIVVDLTH TGPSNRFKTD FLSKWFVVFP GFAYDNVSAV YIYNCNSWVR EYTKYHERLL
TGLKGSKRLI FIDCPGKLAE HIEHEQQKLP AATLALEEDL KVFHNALKLA HKDTKVSIKV
GSTAVQVTSA ERTKVLGQSV FLNDIYYASE IEEICLVDEN QFTLTIANQG TPLTFMHQEC
EAIVQSIIHI RTRWELSQPD SIPQHTKIRP KDVPGTLLNI ALLNLGSSDP SLRSAAYNLL
CALTCTFNLK IEGQLLETSG LCIPANNTLF IVSISKTLAA NEPHLTLEFL EECISGFSKS
SIELKHLCLE YMTPWLSNLV RFCKHNDDAK RQRVTAILDK LITMTINEKQ MYPSIQAKIW
GSLGQITDLL DVVLDSFIKT SATGGLGSIK AEVMADTAVA LASGNVKLVS SKVIGRMCKI
IDKTCLSPTP TLEQHLMWDD IAILARYMLM LSFNNSLDVA AHLPYLFHVV TFLVATGPLS
LRASTHGLVI NIIHSLCTCS QLHFSEETKQ VLRLSLTEFS LPKFYLLFGI SKVKSAAVIA
FRSSYRDRSF SPGSYERETF ALTSLETVTE ALLEIMEACM RDIPTCKWLD QWTELAQRFA
FQYNPSLQPR ALVVFGCISK RVSHGQIKQI IRILSKALES CLKGPDTYNS QVLIEATVIA
LTKLQPLLNK DSPLHKALFW VAVAVLQLDE VNLYSAGTAL LEQNLHTLDS LRIFNDKSPE
EVFMAIRNPL EWHCKQMDHF VGLNFNSNFN FALVGHLLKG YRHPSPAIVA RTVRILHTLL
TLVNKHRNCD KFEVNTQSVA YLAALLTVSE EVRSRCSLKH RKSLLLTDIS MENVPMDTYL
HHGDPSYRTL KENQPWSSPK GSEGYLAATY PTVGQTSPRA RKSMSLDMGQ PSQANTKKLL
GTRKSFDHLI SDTKAPKRQE MESGITTPPK MRRVAETDYE METQRISSSQ QHPHLRKVSV
SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI LYEYLAEASV VFPKVFPVVH
NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY QTSYLQSFGF NGLWRFAGPF
SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE ETSEESLLTP TSPYPPAVQS QLSITANLNL
SNSMTSLATS QHSPGIDKEH VELSPTTGHC NSGRTRHGSA SQVQKQRSAG SFKRNSIKKI
V
//
