ID G1LFT5_AILME Unreviewed; 434 AA.
AC G1LFT5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
GN Name=AMH {ECO:0000313|Ensembl:ENSAMEP00000005774.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005774.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005774.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005774.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; G1LFT5; -.
DR STRING; 9646.ENSAMEP00000005774; -.
DR Ensembl; ENSAMET00000006015.2; ENSAMEP00000005774.2; ENSAMEG00000005474.2.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000006337; -.
DR HOGENOM; CLU_025681_1_0_1; -.
DR TreeFam; TF335595; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 307..434
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 434 AA; 46135 MW; 0D8671BD3FEE9EE0 CRC64;
NASPTPGLSC CVGGWGAMGQ RCGGEGSSAP ASPGEPGTGG LIFHQDWDWP PGSPQDPLCL
VTLDQTGNRS STPLRVAGAL RGYEHAFLEV VQQARWGPRD LTSPARSPRL PVGVGGSPCQ
NARWALGRGL GFSGSGVPSL SVLATVTWEP TFSLKFQDPP PGGASPLELA LLVLYPGPGP
EVTVTGTGLP GTQNLCWSRD TRYLVLAVDH PAGAWHSPGV TLTLQPRGDG HAGAPLSTPQ
LQELLFGHDP RCFTRMTPAL LLLPPPGPTP MPAHGLLDQV PFPPPRCARA VEEEPCTCSY
LPTPPCRPSQ EQEPKEPPPS ADPFLETLTR LVRRLLALRE LSVDLRAERS VLIPETYQAN
NCQGACGWPQ SDRNPRYGNH AVLLLKMQAR GAALARAPCC VPTAYAGKLL ISLSEERIRA
HHVPNMVATE CGCR
//
