ID G1LG00_AILME Unreviewed; 2606 AA.
AC G1LG00;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Telomerase associated protein 1 {ECO:0000313|Ensembl:ENSAMEP00000005839.2};
GN Name=TEP1 {ECO:0000313|Ensembl:ENSAMEP00000005839.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005839.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005839.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005839.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9646.ENSAMEP00000005839; -.
DR Ensembl; ENSAMET00000006083.2; ENSAMEP00000005839.2; ENSAMEG00000005467.2.
DR eggNOG; KOG3602; Eukaryota.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000161338; -.
DR HOGENOM; CLU_000342_0_0_1; -.
DR InParanoid; G1LG00; -.
DR TreeFam; TF328424; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR GO; GO:0070034; F:telomerase RNA binding; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd00200; WD40; 3.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR045804; DUF5920.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008850; TEP1_N.
DR InterPro; IPR008858; TROVE_dom.
DR InterPro; IPR037214; TROVE_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44791:SF1; TELOMERASE PROTEIN COMPONENT 1; 1.
DR PANTHER; PTHR44791; TELOMERASE PROTEIN COMPONENT 1 TEP1; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF19334; DUF5920; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF05386; TEP1_N; 3.
DR Pfam; PF05731; TROVE; 1.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00320; WD40; 16.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF140864; TROVE domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS51226; TEP1_N; 3.
DR PROSITE; PS50988; TROVE; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 192..650
FT /note="TROVE"
FT /evidence="ECO:0000259|PROSITE:PS50988"
FT DOMAIN 1147..1420
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 1825..1866
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1867..1899
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2044..2078
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2090..2130
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2131..2161
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2221..2254
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2263..2294
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2530..2560
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 350..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2487..2528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2606 AA; 287950 MW; 7ECBEB35E3FA3093 CRC64;
MEKLQGHASS HLDILSLENR CLATLPNLQP MKKPHGHVSA HPDILSLENQ CLATLPDLKT
MEKPHGHVSA HPDILSLENR CLATLPVLKS TVSASPLLHC LQRAPLVQAA LRSLPSEPPT
WRAQCLSEGL GCLSCPTALK SVSAKERAPE TALGRCSSSE EKMPEEKERV EVQMPFYNLS
LGEEETLEEP VLKLTAGDSD SHPGPTDQAL KDKKMVLISL LCSTLTSKGN IEDAADPTSG
TLFEVCSELA PLEPEFILKA SLYARQQLNI RTVANKVLAI AAFLPVCRPH LRRYFCAIVQ
LPSDWLQVAE FYEKLAGGEE DKLVPLPACL RAAMTDKFAQ FDEYQLAKYN PRKHRAKRRP
RPPPRPPKTG RPFSETQKYL PRYLRPLKDE QKKFEETYNA VPERKQQPRF TLKKLVRRLH
IREPAQHVQA LLGYRYPSNL QMFSRSRLPG AWDASRAGKR MKLPRPETWE RELSLRGNKA
SVWEELIDSG KLPFMAMLRN LCNLLRAGIS ARHHELVLQR LQHENSVIHS RQFPFRFLNA
HDSIHDLEAR LKSKALPPPS NTKLIRSIMT RNAKKDRNWT YRRYPHPPSR RQLRTTMMMP
VIYEQLKWEK LKIQKARRGK YDGEMMARYR QALETAVNIS AKHNLPPLPG RTVLVYLTDM
GTDELCRKST LQGRPINYVL LLIGMMIARA EQVDLLLCGR GTMKTAVFKA EEGILKTAGT
LLAQVQQGTG DSFLQDLDEE GEWSVNTFGK YLLSLAAQRV PVDRVILFGN TMYNRLVNEA
KQLFWQHVNS KCLFVALPLG RTCDTLPDSN PNNVTLSGYT DGILKFIAER GASRLLEHVG
QMDKIFKVPP PPGKTGDLSL RPLEENTLSP LAPISQPRWR SVRLFISSTF RDMHGERDLL
LRSVLPALQA RAAPHCISLH AIDLRWGVTE EETRRNRQLE VCLGEVENAQ LFVGILGSRY
GHVPPNYNLP DHPHFRWAQQ YPAGRSVTEM EVMQFLDRRL RLRLQPSAQA LLYFRDSGFL
RSVPDAWKSD LTSESEEAAR RISELKSFLS RQQGVTCRRY SCEWGGVAAG RPYAGGLEEF
GQLVLQDVWN MIQQLYLQPG AQLEQPASIA DDDLVQATFQ QLQNPPSPAR PHLLRDTVKQ
LMLRRERLSL VTGQSGQGKT AFLASLVSAL RAPDGAKVAP FIFFHFSGAR PDQGLALTLL
RRLCAYLHCQ LRKPSALPTT YRGLVWEIQQ RLLPEYAQSL RSGQTLVLII DGADRLVDQH
GQPVSDWIPK TLPPRVHLVL SVSTDAGLGD TLEQSQRAHV VALGPLEPSA RARLVREELA
LYGKRLEESP FNNQMRLLLV KRGSSLPLYL RLVTDHLRLY TLYEQVSERL RTLPATVPLL
LQHILGTLEK EHGPDVLPQA LATLEATRSG LTVDQLHAVL SAWRILPRGA KSWEEAVAAG
SSGEPYPMGP FAYLVQSLRS LLGEGPLERA GARLCLPAGP LRTAAQCRYG KRLGLEKTAH
ILIAAQLWKT CDPEASGTFQ NCLPEALADL PYHLLQSGNR GLLAKFLTNI HVVAAHLELG
LVSRLLEAHA LYDEITSSVP KDEQSLPEAD VAVFHTFLRQ QAPVLSQYPL LLPQQAANQP
LDSPLCRQAP QLSRRWRLQH VLRWLNKPHT MEGQQSSSLS LAVSSSPTAV ALSPSGQRAA
VGTASGMVYL LDLRTWQEKS LVSGCDGVSS CSFLSDNALF LTAFDGLLEL WDLQQGCRVL
QTSAHKYQIT GCCLSPDRRL LATVCLGGCL KLWDTVRGQL AFQHAGPRPL NCVAFHPEGQ
MVAVGSWAGS FSLFHVDGLK AAKDLGAPGA SVRTVAFSVP GRVVAVGRLD GMVELWSWHE
GAQLAAFPAH HGIVATALFL RAGRQLLTAG EDGKVQVWSG SLGRPRGCLG SLSLSPALSV
ALSPDGDRVA IGYRADGIRI YKIASGSQGA QCQALDVAVS ALVWLSPKVL VSGAEDGSLQ
GWALKESSLQ SLWLLSRYQK PVLGLATSSE LLASASEDFT VRLWPRQPLT LAQTAEDFPC
GTELREHEGP VSCCRFSSDG GRLATGGRDR NLFCWDVRMP KAPVLICSFS ACHRDWVTGC
DWTKDNLLVS CSTDGSVGLW DPERQQQLGQ FLGHQSAVSA VVAVEEHVVS VGRDGTLKVW
DHQGVELTSI PAHSGPISHC AAALEPRAAG QPGSELLVVT VGLDGATRLW QPLLVFQTHT
FLGHSGPVSA AAVSETSGLL LTTSEDGSVR LWQVPEEADD AYMPRSPAAI TAVAWAPDGS
MAASGNRTGE LTLWHKAKAV ATAQAAGHIS ALLWYAARTL IVLSNNEKVS EWQVELQEGS
TPRNFSLHLT RVLQEDLGFL TGVALAPDGH SLILADAGLQ LQHVKPGEAP SVIWSSNYSE
CAMLLSTHQD YGVFVLQPME PGGLFSLRQK EAGEFEESLE FKPDLENPTG TFVLVTQAKP
ESESSFLCAS SDGMLWKLAK RTPEGEWETG DIWQKREMPE TPTPETASSV NDSSAYSWSP
PPQLSTQQRR KIHSGSVTAL HVLPGLLVTA SKDRDVKLWE RPSMQLLGLF QCEAAVSCLE
PWLGPDSTLQ LAVGDTLGNV YFLSWE
//
