ID G1LG13_AILME Unreviewed; 4011 AA.
AC G1LG13;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSAMEP00000005852.1};
GN Name=FRAS1 {ECO:0000313|Ensembl:ENSAMEP00000005852.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005852.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005852.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_002912530.1; XM_002912484.3.
DR STRING; 9646.ENSAMEP00000005852; -.
DR Ensembl; ENSAMET00000006096.2; ENSAMEP00000005852.1; ENSAMEG00000005463.2.
DR GeneID; 100470155; -.
DR KEGG; aml:100470155; -.
DR CTD; 80144; -.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000162130; -.
DR HOGENOM; CLU_000244_0_0_1; -.
DR InParanoid; G1LG13; -.
DR OMA; NSGMRVQ; -.
DR OrthoDB; 5470912at2759; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR CDD; cd00064; FU; 13.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..4011
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003414560"
FT TRANSMEM 3905..3925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..88
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 93..153
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 157..217
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 219..279
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 283..343
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 347..417
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1101..1196
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1216..1307
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1328..1437
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1462..1558
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1594..1688
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1709..1809
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1832..1935
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1956..2056
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2077..2176
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2198..2290
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2310..2403
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2438..2535
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 4011 AA; 441647 MW; 52A63BE674905B20 CRC64;
MGAFKVWFGV ALALAGFATL PHHSEGACVY QGSLLADATT WKPDSCQNCR CHGNIIICKP
AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK IYAHGTEWAS SPCSVCSCTH
GEVRCSPQPC PALLCGQQEL EFIPEGSCCP VCVGPGKPCS FEGRVFQDGE DWPLSRCAKC
VCRDGVAQCF TAQCQPLFCN QDEAIVRVPE KCCPQCSSRS CSASGQVYEH GEQWNENACT
TCICDKGEVR CHKEACPPLR CEKGQSRAQR PGECCEECVS PAGSCSHNGI VRYQDEMWKG
SACEFCMCDH GQVICQTGEC AKVECAQGEE LVHLDGKCCP ECISKNGYCV HEENAEFISS
NASEVKRIPE GEKWEDGPCK VCECRGSQVT CYEPSCSPCP VATLAQVVKG RCCPDCTSVH
CHPDCLTCSQ SPEHCDLCQD PTKLLRNGQC VHSCGLGFYQ AGAVCLACQP QCSTCTSRLE
CSSCQPPLLM RHGQCVSTCG DGFYQDRHSC AVCHESCAAC WGPTEKHCLA CRDPLQVLRE
GGCESSCGLG FYGKQGICRA CDQSCKSCGP NSPRCLTCAE KTVLHDGKCI AECPGGYYAE
ATGRCEACHN SCASCSGPTG SHCTACIQPR ALRQGHCLSS CGEGFYPDHG VCRACHSSCL
TCVGPEPSQC AQCKKPDEGL QVEQLSGANI TSGECLSQCR AQFYLDNTGL CEACHQSCLR
CAGKSPHNCT ACWPSQVLLD GQCLSECPDS YFNQEGSCIE CHPTCRQCHG PSESDCSSCH
PHVALAGGSC RTSCKEEQFL NLVGYCTDCH PLCRHCAADL QHTGSICLSC QNARYLLLGD
HCVPDCPSGL YADRGACKKC HSSCRTCQGT GPFSCTSCDA DLVLSHLGTC STACFPGHYL
DDSRACQPCE AHCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STKICKECDW
SCNACSGPLR TDCLQCMDGY VLQDGACVEQ CSPAFYRDLG LCKSCGNHCL QCQGPHECTR
CEGPYLLLEA QCVQECGKGY FADYANRQCA ACPQACLQCS RRDQCHRCDH GFFLKSGLCV
SNCVPGFSAH SNETCAGKIY TPSLHVNGSL TLAIGSMKPL DFPLLNVQDQ YGRVEDLQFH
VVSTPTNGQL VLSRNGKEVQ LDKAGHFSWK DVNEKKVRFV HSKEKPRKGY FSLKISDQQF
FSEPQLINIQ AFSTQAPYVL RNEALRISRG ERGTITTQLL DIRDDDNPQD VVVQVLDPPL
HGQLLQTLPS PATPIYQFRL DELSRGLLHY AHDGSDSLSD VAVLQANDGH SFRNILFHVK
MVPKNDASLR LVANSMVWVP EGGMLQITNR ILQAEAPGAS ASEIIYKITQ GHPQFGEVVL
LVDMPADSPA EEGQHLPDGR TATPTSTFTQ QDINEGIVWY RHSGVPAQSD SFLFQVSSAA
DAHMHLESRT FNIAILPQTP EAPKLSLGAS LHMTAREDGL TVIQPHSLSF VNSESPSGKI
IYNITLPLHP NQGIIEHRDQ PHSPIQYFTQ EDINQGKIMY RPPPAAPHLQ EIMAFSFAGL
PESVKFHFTV SDGAHTSPEM VLTIHLLPTD QHLPAFLVTA PLLEVSPGGS TAIGLQLEVR
DAEITPEELL FELRKPPEHG VLLKYTAELQ GPMATGDTFT YEDIEKNVLQ YLHDGSSAQE
DSMEISVTDG TSATTVDVKV EVSLSEDRGP QLSAGASLSI TVASKSTTVI TRSHLAYVDD
SSPDSEIWIQ LSSLPMYGAL LRVSGPEVEE LSEVSNFTME DINNQKIRYS AVYETDGNLV
TDGFHFSVSD MDHNHLDNQM FTIMITPVEN PPPVIAFADL ITVDEGGRAP LSFHHFFAAD
DQDNLQGDAI IKLSALPKYG CIENTGTGDR FGPGATSDLE ASFPIQDVLE NYIYYFQSVH
ESIEPTHDIF SFYISDGNSR SEIHSINITI ERKNDEPPRI TLRPLGVQLS SGVVISNSSL
SLQDLDTPDN ELVFVLTKKP DHGHLLWRQT ASEPLENGRI LTQGSSFTYQ DVLAGLVGYM
PGGPGVAVDE FRFSLTDGLH VDTGRMEIYI ELPTSGAPNL AINRGLQLSA GSVARITEQH
LRVTDTDSDD RQVMYIMKED PGAGRLQMIK HDNPEQISVK GPIRSFTQAD ISQGQVEYRH
GKGESGGSFA FKFDVVDGEG NMLIGQSFSI NVLEDNSPPV ITTNKGLVLD ENSVEKITTL
QLSATDQESK PTDLIYTISR QPELGHLEHA ASPGIQISSF TQADLTSRNI QYIHSSDTEK
HSDVFSFTLS DGVSEVTQTF HITIRPVDDS LPVVQNLGMR VQEGVSKTIT EFELKAVDAD
TEAESVTFTI VQPPRHGTIE RTTNGQHFRH TSTFTMEDIY QNRVSYSHDG SNSLRDRFTF
TVADGTNPFF IIEEGGKEVM TAAPQHFQVD ILPVDDGTPR IVTNLGLQWL EYMDGKATNL
ITKKELLTMD PDTEDLHLVY EITAGPKHGH VENKLQPGRA AVTFTQEDVN LGLIRYVLHE
EKIREMMDSF QFLVKDSKPN VVSDNVFHVQ WSLISFKYTS YNVSEKAGSV SVTVQRSGNL
NQYAIVLCRT EQGTASSSSR VSSQPGQQDY VEYAGQVQFD EREDTKSCTI VINDDDVFEN
VESFTVELSM PAYALLGEFT QAKVIINDTE DEPTLEFDKK TYRVNESAGF LFAPIERKGD
SSSIVSAICY TVPKSAMGSS LYALESGSDF KSRGMSPDSR VIFGPGVTVS TCDVMLIDDS
EYEEEEEFEI VLADASDNAR IGRVASAKVL ISGPNDASTV SLGNTAFTVS EDAGTVKIPV
IRHGTDLSTF TSVWCATRPS DPASATPGVD YVPSSRKVEF GPGVTEQYCT LTILDDTQYP
VIEGLETFVV FLSSAQGAEL TKPFQAVIAI NDTFQDVPSM QFAKDLLLVN EKEGVLQVPI
IRSGDLSYES SVRCYTQGHS AQVMEDFEER RNADSSRITF LKGEKMKNCT VSIHDDSMFE
PEEQFRVYLG HPLGNHWSGA RIGKNNMATI TISNDEDAPT IEFEEAAYQV REPSGPDAVA
LLNIKVIRRG DQNRTSKIRC STRDGSAQSG VDYYPKSRVL KFSPGVDHIF FKVEILSNED
REWHESFSLV LGPDDPVEAV LGDVTTATVT ILDQEAAGSL ILPAPPIVVT LADYDHVEEV
TKEGVKKSPS PGYPLVCVTP CDSHFPKYAI MKERCSEAGI NQTSVQFSWE VATPTDGNGA
RSPFETITDN TPFTSVNHMV LDSIYFSRRF HVRCVAKAVD KVGHVGTPLR SNIVTIGTDS
AICHTPVVAG TARGFQAQSF IATLKYLDVK HKEHPNRIHI SVQIPHQDGM LPLISTMPLH
NLHFLLSESI YRHQHVCSNL VTTRDLRGIS EAGFLDDRVY DSTALGPGYD RPFQFDPSVR
EPKTIQLYKH LNLKSCVWTF DAYYDMTELI DVCGGSVTAD FQVRDSAQSF LTVHVPLYVS
YIYVTAPRGW ASLEHHTEME FSFFYDTVLW RTGIQTDSVL SARLQIIRIY IREDGRLIIE
FKTHAKFRGQ FVMEHHTLPD VKSFILTPDH LGGIEFDLQL LWSAQTFDSP YQLWRATSSY
NRKDYSGEYT IYLIPCTVQP TQPWADPGEK PLACTAHAPE RFLIPIAFQQ TNRPVPVVYS
LNTEFQLCNN EKVFLMDPNT SDMSLAEMDY KGAFSKGQIL YGRVLWNPEQ NLNSAYKLQL
EKVYLCTGKD GYVPFFDPTG TIYNEGPQYG CIQPNKHLKH RFLLLDRSQP EVTDKYFHDV
PFEAHFASEL PDFHVVSSMP GVDGFTLKVD ALYKVEAGHQ WYLQVIYVIG PDTISGPRVQ
RSLAAPLRRN RRDLVDPSGH LTLDDSLIYD NEGDQVKNGT NMKSLNLDMQ APAVAASLSQ
TGASLGSALA AIMLLLLVLL VACFLTRKCQ RQRRKTPTED ILEEYPLNTK VDVSKRSPDR
VEKNSNRHYC TVRNVNILSE AEGAYAFKGA KVKKLNLEVR VHNNLQDGTE V
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