ID G1LGB7_AILME Unreviewed; 483 AA.
AC G1LGB7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Colony stimulating factor 2 receptor subunit alpha {ECO:0000313|Ensembl:ENSAMEP00000005956.2};
GN Name=CSF2RA {ECO:0000313|Ensembl:ENSAMEP00000005956.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005956.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005956.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005956.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G1LGB7; -.
DR STRING; 9646.ENSAMEP00000005956; -.
DR Ensembl; ENSAMET00000006203.2; ENSAMEP00000005956.2; ENSAMEG00000005635.2.
DR eggNOG; ENOG502RZVR; Eukaryota.
DR GeneTree; ENSGT00520000055993; -.
DR HOGENOM; CLU_039627_2_0_1; -.
DR TreeFam; TF331549; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040907; IL3Ra_N.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF179; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF18611; IL3Ra_N; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..373
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 483 AA; 55379 MW; 211957BB94E9903E CRC64;
MSRQCNQCVH FLTRQRAVQE NGQMLERRET EQESRWPGQS LVRWGCPRLS GSPMGLGATA
ILFCMLLDPV FLQTLEQQDL PTVAGIPSLN MKFDSWRMEL SWDCKENTTY LECVMIHKDK
GPIEITPQEK ECHCKFSDYS LHDGVTLMVK VNSTQRPIPE TLVYTNAGGE GTAAQNFSCF
IYNANFMNCS WAKGQAAPDD VQYFLYIRDS RKKRERECPC YIEDSGTHVG CHLEDLSGLA
SYNYFLVNGT SQGTGIQFFD SVLSWKKIEI FSPPNNISVH CTRSHCLIQW EKPKTRHNLP
NWEFKYQLDI QKQSNKEHSE NQPIEVSGNW ENNYNFPSPE PRAKHTVKIR ASDARIEKWG
AWSQAVEFGS KEPEPSLVPT YALVVLGTFL TALILGCLLK RFFASERLFP PIPRIKDKWD
DSHQCDHQVI WENFTLDTEK ADNEEILTVE EVTVTPGNKE TFLALRRLRC LSASRQLGWD
VGL
//
