ID G1LGD9_AILME Unreviewed; 1410 AA.
AC G1LGD9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
GN Name=TONSL {ECO:0000313|Ensembl:ENSAMEP00000005978.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005978.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005978.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005978.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR STRING; 9646.ENSAMEP00000005978; -.
DR Ensembl; ENSAMET00000006226.2; ENSAMEP00000005978.2; ENSAMEG00000005645.2.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160188; -.
DR HOGENOM; CLU_002128_0_0_1; -.
DR InParanoid; G1LGD9; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005662; C:DNA replication factor A complex; IEA:Ensembl.
DR GO; GO:0035101; C:FACT complex; IEA:Ensembl.
DR GO; GO:0042555; C:MCM complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0140566; F:histone reader activity; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00367; LRR_CC; 2.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT REPEAT 565..597
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 598..630
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 634..666
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 496..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..529
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1410 AA; 153552 MW; AE36C429DB440D46 CRC64;
MLRAAELHFP GCSAPNRGGA WGGAAAGARE VRMPARGCWS TNMERELRQL SKAKAKAQRS
GQLRDEAALC HQLGELLASH GRYAEALREH QHELQLLESV DDPLGCAVAH RKIGERLAEL
EDYSAALKHQ HRYLELAHSL SNHTEVQRAW ATIGRTYLDI YDHCQSQDTL LQAQTAFEKS
LAIVDEKLQG TLAKRELSEM RTRLYLNLGL TFESLRQMAP CNDYFRKSIF LAEQNHLYED
LFRARYNLGA IHWRRGQHSQ AMRCLEGARE CARVLRKELM ESECCMLISQ ILQDLGDFLA
AKRALKKAYR LGIQKPLQKA AVCRALKYVL AVVRLQQQLQ ESEGSDPQGA MGICEQLGDL
FSKAGDFPKA AEAYQKQLHF AELLGRPGPE LAIIHVSLAT TLGDMKDYRR AVSHYEQELR
LRGGDALEEA KTWLNIALSR EEAGDAYELL APCFQKALSC AQQAQRPQLQ RQVLQHLHTV
QLRLQPQEAP VTAATLQELS VPRDQEDDDE EEKEGDGDTP EASDVELSES EGDAEGRSQQ
LEEDEELQGC LGQQRVNKWN RRNDVGETLL HRACIEGRLG RVQDLVRQGH PLNPRDYCGW
TPLHEACNYG HLDIVRFLLD HGAVVDDPGG PGCEGITPLH DALHCGHFEV AELLIERGAS
VTLRTMKGHS PLETLQQWVK LYGKDLDSET REKAGSMESL LRAASSGQAP HSSLAPHILP
RNHLFDPEIS PPSSPCPGPP ETSQARAGVS PGQAVPAAAR PRRTRHNLAS SSSSEGEDNP
GPPRPVQKRP RHYVPAQQAR TGVPGSTSSR EAVAVSATRA AVRGVGGAQI CCPGPGLRWG
PGEPTPPRAA LIPEEACLAG DWLEDDSPLT HSHQGGYLPH PQGSGDGTRP GGLGSGGSKS
PGRLRARARQ SRLPRLRSWN ALSRAGGDSS AAELPRSPDM SRASGPSGDS PAAGQPLGPS
LPPPIRVRVR VQDSLFLIPV PHSRETHSVA WLAEQAAQRY CQACGLLPRL VLRKEGALLA
PQDPIPDVLQ SNEEVLAEVT SWDLPPLTDR YRRACQSLEQ EEDQEVLQAV DRQGSGPSFS
ACSLALHQTQ LTPLLRALKL HTALRELHLA GNRLGDGCAA ELLAALGTMP SLVLLDLSSN
HLGPEGLRQL ATGLQGQTAL QNLQELDLSM NPLGDGCGRA LAFILQACPS LSTLHLQACG
FGPSFFLSHQ AALGSAFQDA KHLQTLSLSY NILGTAALAH ALQNLPAHNL QRLELSSVAA
SKSDSGLVEP VVRYLTKEGC VLAHLSLSAN HLGDKAVGDL SRCLPCCPSL ISLDLSANPE
ISCVGLEELL SALQMRPQDL SFLGLSGCAV QGPLGLGLWR EITTRVHELQ LCSRRLSPED
RAALRQLLPG QPGPGACSLD RGPKLFFRRL
//
