ID G1LI05_AILME Unreviewed; 1361 AA.
AC G1LI05;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Cell migration inducing hyaluronidase 1 {ECO:0000313|Ensembl:ENSAMEP00000006553.2};
GN Name=CEMIP {ECO:0000313|Ensembl:ENSAMEP00000006553.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000006553.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000006553.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000006553.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CEMIP family.
CC {ECO:0000256|ARBA:ARBA00007586}.
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DR STRING; 9646.ENSAMEP00000006553; -.
DR Ensembl; ENSAMET00000006829.2; ENSAMEP00000006553.2; ENSAMEG00000006176.2.
DR eggNOG; ENOG502QT0K; Eukaryota.
DR GeneTree; ENSGT00940000153636; -.
DR HOGENOM; CLU_005606_1_0_1; -.
DR InParanoid; G1LI05; -.
DR TreeFam; TF316575; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Ensembl.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0046923; F:ER retention sequence binding; IEA:Ensembl.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd13938; PANDER_like_TMEM2; 1.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR039473; TMEM2_PANDER-like.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR15535:SF15; CELL MIGRATION-INDUCING AND HYALURONAN-BINDING PROTEIN; 1.
DR PANTHER; PTHR15535; TRANSMEMBRANE PROTEIN 2-RELATED; 1.
DR Pfam; PF10162; G8; 1.
DR Pfam; PF15711; ILEI; 2.
DR Pfam; PF13330; Mucin2_WxxW; 2.
DR SMART; SM01225; G8; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1361
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170848"
FT DOMAIN 44..166
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
SQ SEQUENCE 1361 AA; 151973 MW; 91FA966A70435BE6 CRC64;
MGAASGQDVS FKAVLTLSWL MLACLPGAAT TATAECPDQS PELQLWNPGH DPDHSVYIGR
GRTLLLTSSA TVNSIHVSEG GKLVIKDHEE TIVLRTRHIL IDAGGELHAG SARCPYQGRF
SIVLYGRADD GLQPDPYFGL KYIGVGPGGT LELHGQKKLS WTFLNKTLRP GGMEEGGYFF
ERSWGHRGVI VHVIDPKSAT VIHSDRFDTY RSKKESERLV QYLNAVPAGR ILSVAVNDEG
SRNLDDAARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVS
KVFQTEHGEH FNVSSSSEWV QDVEWTEWFD QDKVSHAKGG DKISDVQAAH PGKICNRPIH
IQAMTVDGVN LTTEVVYKKG QDYRFVCYDQ GRACQTYRVR FLCGKPVRPK LTVTIDTNVN
STILTLEDDV QSWKPGDTLV VASTDYSMYQ AEEFQVLPCK ACASNQVRVA GKPLYLHIGE
EIDGVDMRAE VGLLTRNIVV MGEMEDSCYP YSSHICSFFD FDTFGGHIKF ALGFKAAHLE
GVELKHMGQQ LVGQYPIHFH LAGDVDEKGG YDPPTYVREL SIHHTFSRCV TVHGSNGLLV
KDVVGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKT ITEDSYPGYI
PKPRQDCNAV STFWMANPNN NLVNCAAAGS EETGFWFIFH HVPTGPSAGM YSPGYSEHIP
LGKFHNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI
IRHFTAYKNQ DHGAWLRGGD VWLDSCRFAD NGIGLTLASG GTFPYDEGSK QEIKNSLFVG
ESGNVGTETM DNRIWGPGGL DHSGRTLPIG QNFPIRGIQF YDGPINVQNC TFRKFAALEG
RHTSALAFRL NNAWQSCPHN NVTNIAFEDV PITSRVFFGE PGPWFNQLDM DGDKTSLFHD
VDGSVSEYPG SYLTKDDNWL VRHPDCINVP DWRGAICSGR YAQMYIQAYK TSNLRMKIIK
NEFPNRPLYL EGALTRSTHY QQYQPVVTLQ KGYTVHWDQT APAELTVWLI NFNKGDWIRV
GLCYPRGTTF SILSDVHDRL LKHTSKTGTF VRSLQMDKLG QSLPGRSHYY WDEDSGLLFL
KLKAHNERER FAFCSVKGCE RIKIKALIPK NAGVSDCTAT AYPRFAERPV VDVPMPRKLL
GAQLKTKDHF LEVKMESSRQ RFFHLMNDFA YIEVDGTKYP SAEDGIQVVA IDGSQGHVLS
DTSFRHAILQ GIPWQLLEHM AAIPDNSIVL MVSKGRYTSR GTWTRVLENL GADKSIKLKE
KMAFVGFKGS FRPTWVTLDT DDDKAKIFQA VPIPVVQKQQ L
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