ID G1LI85_AILME Unreviewed; 405 AA.
AC G1LI85;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Corticosteroid-binding globulin {ECO:0000256|ARBA:ARBA00039186};
DE AltName: Full=Serpin A6 {ECO:0000256|ARBA:ARBA00043180};
DE AltName: Full=Transcortin {ECO:0000256|ARBA:ARBA00041777};
GN Name=SERPINA6 {ECO:0000313|Ensembl:ENSAMEP00000006633.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000006633.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000006633.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000006633.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Major transport protein for glucocorticoids and progestins in
CC the blood of almost all vertebrate species.
CC {ECO:0000256|ARBA:ARBA00037222}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; G1LI85; -.
DR STRING; 9646.ENSAMEP00000006633; -.
DR Ensembl; ENSAMET00000006913.2; ENSAMEP00000006633.2; ENSAMEG00000006300.2.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000161611; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; G1LI85; -.
DR TreeFam; TF343201; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
DR CDD; cd19554; serpinA6_CBG; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF34; CORTICOSTEROID-BINDING GLOBULIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..405
FT /note="Corticosteroid-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170854"
FT DOMAIN 47..404
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 405 AA; 45634 MW; B7B895519C44240F CRC64;
MLLALCTYFL WLSTTDLWTV QAKDPDTDVS PRTPHRDLAP SNVDFAFILY RHLVASFPGK
NVFISPVSIS MALAMLSLGA RGYTRVQLLQ GLGFNLTKMS EAEIHQGFQH LRHLFEKESD
TMLEMAMGNA LFLDRNLELL ESFLADTKNY YEVEALAADF KDGPGASRQI NEYIKNKTQG
KIVDLSSKLD SSAMLILVNY IFFKGTWEHP FDPESTREEN FYVNKTTVVR VPMMFQSGTI
KYLHDQVLPC LLVQLEYLGN GTVFFILPEE GKMDTVIAAL SRDTIQRWSE SLTTGQVNLY
VPRVVISGAY DLRAILGDMG IADLLDKEAD FSGITREAPL KLSKVVHKAV LQLDEKGLEA
ATCPRVMLEG ASEPLTFRFD RPFLLMIFDH FSWSSLFLGK VVNPT
//
