ID G1LL68_AILME Unreviewed; 1828 AA.
AC G1LL68;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dedicator of cytokinesis 1 {ECO:0000313|Ensembl:ENSAMEP00000007690.2};
GN Name=DOCK1 {ECO:0000313|Ensembl:ENSAMEP00000007690.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000007690.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000007690.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000007690.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9646.ENSAMEP00000007690; -.
DR Ensembl; ENSAMET00000008011.2; ENSAMEP00000007690.2; ENSAMEG00000007297.2.
DR eggNOG; KOG1998; Eukaryota.
DR GeneTree; ENSGT00940000154974; -.
DR HOGENOM; CLU_000595_1_0_1; -.
DR InParanoid; G1LL68; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08694; C2_Dock-A; 1.
DR CDD; cd11707; DHR2_DOCK1; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR047026; DOCK1_C2.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 435..619
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1167..1577
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1572..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 174..201
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1593..1622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1786..1816
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1828 AA; 210764 MW; 6A730A664D47BDC2 CRC64;
PSGAAFYNYD ARGADELSLQ IGDTVHILET YEGWYRGYTL RKKSKKGIFP ASYIHLKEAI
VEGKGQHETV IPGDLPLVQE VTTTLREWST IWRQLYVQDN REMFRSVRHM IYDLIEWRSQ
ILSGTLPQDE LKELKKKVTA KIDYGNRILD LDLVVRDEDG NILDPELTST ISLFRAHEIA
SKQVEERLQE EKSQKQNIDI NRQAKFAATP SLALFVNLKN VVCKIGEDAE VLMSLYDPGE
SKFISENYLV RWSSSGLPKD IDRLHNLRAV FTDLGSKDLK RDKISFVCQI VRVGRMELRD
NNTRKLTSGL RRPFGVAVMD VTDIINGKVD DEDKQHFIPF QPLALDDAIR HKPLNMSSRF
SPRVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRTTAVA
RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLEHVIFPGA
GDEAISEYKS VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA
LAFVKLMRYD GTTLRDGEHD LIVYKAEAKK LEDAATYLSL PSTKAELEEK AHSATGKSMQ
SLGSCTISKD SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL
AYTKLTKVLR NYVDNAEKPV INDQLYKAMK ALEYIFKFIV RSRILFNQLY EDKGEADFME
SLLQLFRSIS AMMSSVSDQT VRVKGAALKY LPTIVNDVKL VFDPKELSKM FTDFILNVPM
GLLTIQKLYC LIEIIHSDLF TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV
LYRKDVGPTQ RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL
IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNM MQNKVFLRAI NQYADMLNKK
FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK ILNKYGDMRR QIGFEIRDMW
YNLFENEIIT KLDHEVEGGR GDEQYKVLFD KILLEHCRKH KYLAKTGETF VKLVVRLMER
LLDYRTIMHD ENKENRMSCT VNVLNFYKEI EREEMYIRYL YKLCDLHREC DNYTEAAYTL
LLHAKLLKWS EDVCAAHLTQ RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL
AEQYENEMFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPT FLRGKVFIYR
GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKNSPGQ YIQCFTVKPK LDLPPKFHRP
VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP DNEFANMWIE RTIYTTAYKL PGILRWFEVK
SVFMVEISPL ENAIETMQLT NDKMNSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN
YEKAFFTERY LQEHPEAHEK IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC
FKQLKEKVEK QYGVRTMPSS LDDRRGSRPR SMVRSFTMPS SSRPLSVASV SSLSSDSTPS
RPGSDGFALE PLLPKKMHSR SQDKLDKDDP EKEKKDKKKE KRNSKHQEIF DKEFKPTDMS
VQQSEAVILS ETISPLRPQR PKSQVINVTG SERRFSVSPS SPSSQPAPPP VAPRAKLSFS
LQSSLELNGM TSMTAMDTAE VPPPLPLKGG MADYGNLLEN QDLISSPTPP HPPPHQRHVP
PPLPSKTPPP PPPKTTRKQT SVDSGIVQ
//
