ID G1LLA4_AILME Unreviewed; 1243 AA.
AC G1LLA4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSAMEP00000007726.2};
GN Name=PPFIA1 {ECO:0000313|Ensembl:ENSAMEP00000007726.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000007726.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000007726.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000007726.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; G1LLA4; -.
DR STRING; 9646.ENSAMEP00000007726; -.
DR Ensembl; ENSAMET00000008047.2; ENSAMEP00000007726.2; ENSAMEG00000007203.2.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT01050000244900; -.
DR HOGENOM; CLU_006923_0_0_1; -.
DR TreeFam; TF314207; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 898..964
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1011..1068
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1092..1161
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 19..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 479..527
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 234..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 140130 MW; FBC796E273B7CB94 CRC64;
MTGVWVFSFK MMCEVMPTIS EAEGPPGGSG SHGSGSPSQP DADSHFEQLM VSMLEERDRL
LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC REQLLEREEE
IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH
HKALDEKVRE RLRVALERCS LLEEELGATH KELMILKEQN NQKKTLTDGV LDMNHEQENT
PSTNGKRSSD GSLSHEEDLA KVIELQDIID KQSKEQSQMK ERLAALSSHV AELEEDLDTA
RKDLIKSEEV NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI
ANKDSMHRQT EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA ALSKAEERHG
NIEERLRQME AQLEEKNQEL QRARQREKMN EEHNKRLSDT VDKLLSESNE RLQLHLKERM
AALEDKNSLL REVETAKKQL EEAQHDKDQL VLNVEALRAE LDQTRLRGMP LHHGRPHLGS
VPDFRFPVAD GPTDSYSSSA VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV
AQAFESDVDV SDGEDDRDTL FSSAALLSPS GQADAQTLAM MLQEQLDAIN KEIRLIQEEK
ESTEQRAEEI ESRVGSGSLD SPGRFRSVGA ATQHPTSTLT GPSPPHSGHS TPRRGPHSPA
REVDRLGVMT LPSDLRKHRR KLPASREEVR DDKATIKCET SPPSSPRSLR LDRLHKGALH
TVSHEDIRDV RNSTGSQDGP VSNPSSSNSS QDSLHKAPKK KGIKSSIGRL FGKKEKGRPG
HAGKEPTGPA ATAETENSSQ DALGLSKLGG QAEKNRKLQK KHELLEEARR QGLPFAQWDG
PTVVVWLELW VGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE
IMSLTSPSAP PTSRTTTGNV WLTHEEMETL TATPQTTLAY GDMNHEWIGN EWLPSLGLAQ
YRSYFMECLV DARMLDHLTK KDLRGQLKMV DSFHRNSFQC GIMCLRRLNY DRKELERKRD
ESQNEIKDVL VWSNDRVIHW ILSIGLKEYA NNLVESGVHG ALMALDETFD ANALALLLQI
PTQNTQARAV LEREFNNLLV MGTDRRFDED DDKSFRRAPS WRKKFRPKDV RGLAAGSAET
LPANFRVTSS LSSPSMQPKK MQLDGSVSGP QRLDSATVRT YSC
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