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Database: UniProt
Entry: G1LLX4_AILME
LinkDB: G1LLX4_AILME
Original site: G1LLX4_AILME 
ID   G1LLX4_AILME            Unreviewed;       772 AA.
AC   G1LLX4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-OCT-2019, entry version 59.
DE   SubName: Full=Tripartite motif containing 28 {ECO:0000313|Ensembl:ENSAMEP00000007951};
GN   Name=TRIM28 {ECO:0000313|Ensembl:ENSAMEP00000007951};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000007951, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000007951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000007951}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; ACTA01008911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01016911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000007951; -.
DR   Ensembl; ENSAMET00000008282; ENSAMEP00000007951; ENSAMEG00000007515.
DR   eggNOG; ENOG410ITES; Eukaryota.
DR   eggNOG; ENOG41102KI; LUCA.
DR   GeneTree; ENSGT00940000160527; -.
DR   InParanoid; G1LLX4; -.
DR   OMA; DANQQCC; -.
DR   TreeFam; TF106455; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005719; C:nuclear euchromatin; IEA:Ensembl.
DR   GO; GO:0005720; C:nuclear heterochromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0090575; C:RNA polymerase II transcription factor complex; IEA:Ensembl.
DR   GO; GO:0070087; F:chromo shadow domain binding; IEA:Ensembl.
DR   GO; GO:0035851; F:Krueppel-associated box domain binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR   GO; GO:0043045; P:DNA methylation involved in embryo development; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR   GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR   GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
DR   GO; GO:0045869; P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1902187; P:negative regulation of viral release from host cell; IEA:Ensembl.
DR   GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
DR   GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR   GO; GO:0090309; P:positive regulation of methylation-dependent chromatin silencing; IEA:Ensembl.
DR   GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:2000653; P:regulation of genetic imprinting; IEA:Ensembl.
DR   CDD; cd00021; BBOX; 1.
DR   CDD; cd16765; RING-HC_TIF1beta; 1.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR003649; Bbox_C.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR037373; KAP1.
DR   InterPro; IPR042713; TIF1beta_RING-HC.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR25462:SF274; PTHR25462:SF274; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00643; zf-B_box; 2.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00502; BBC; 1.
DR   SMART; SM00336; BBOX; 2.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50119; ZF_BBOX; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01011399};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Zinc {ECO:0000256|SAAS:SAAS01006535};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146,
KW   ECO:0000256|SAAS:SAAS01007077}.
FT   DOMAIN        3     59       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   DOMAIN       86    133       B box-type. {ECO:0000259|PROSITE:
FT                                PS50119}.
FT   DOMAIN      142    183       B box-type. {ECO:0000259|PROSITE:
FT                                PS50119}.
FT   DOMAIN      562    609       PHD-type. {ECO:0000259|PROSITE:PS50016}.
FT   REGION      346    417       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      468    555       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      751    772       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    370    384       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   772 AA;  83436 MW;  E06BA4E18CB33D26 CRC64;
     XHCGVCRERL RPEREPRLLP CLHSACSACL GPSAPALGEG IGVGSQHGDG AVVDCPVCKQ
     QCFSKDIVEN YFMRDSGSKA ATDSQDANQC CTSCEDNAPA TSYCVECSEP LCETCVEAHQ
     RVKYTKDHTV RSTGPAKSRD GERTVYCSVH KHEPLVLFCE SCDTLTCRDC QLNAHKDHQY
     QFLEDAVRNQ RKLLASLVKR LGDKHATLQK NTKEVRSSIR QVSDVQKRVQ VDVKMAILQI
     MKELNKRGRV LVNDAQKVTE GQQERLERQH WTMTKIQKHQ EHILRFASWA LESDNNTALL
     LSKKLIYFQL HRALKMIVDP VEPHGEMKFQ WDLNAWTKSA EAFGKIVAER PGTNSTGPTS
     MAPPRAPGPL SKQSSGSSQP MEVQEGYGFG SDDPYSSAEP HVSGVKRSRS GEGEVSGLMR
     KVPRVSLERL DLDLTADSQP PVFKVFPGST TEDYNLIVIE RGAAAAAAGQ PGTAPPGAPG
     APPLPGMAIV KEEETEAAIG APPSAAEGPE TKPVLMALAE GPGAEGPRLA SPSGSTSSGL
     EVVAPEGTSA PAGGPGALDD SATICRVCQK PGDLVMCNQC EFCFHLDCHL PALQDVPGEE
     WSCSLCHVLP DLKEEDGSLS LDGGDSTGVV AKLSPANQQK CERVLLALFC HEPCRPLHQL
     ATDSTFSLDQ PGGTLDLTLI RARLQEKLSP PYSSPQEFAQ DVGRMFKQFN KLTEDKADVQ
     SIIGLQRFFE TRMNEAFGDT KFSAVLVEPP PLSLPSAGLS AQELSSGPGD GP
//
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