ID G1LPH2_AILME Unreviewed; 544 AA.
AC G1LPH2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Checkpoint kinase 2 {ECO:0000313|Ensembl:ENSAMEP00000008952.2};
GN Name=CHEK2 {ECO:0000313|Ensembl:ENSAMEP00000008952.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000008952.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000008952.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000008952.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011218533.2; XM_011220231.2.
DR RefSeq; XP_019651261.1; XM_019795702.1.
DR RefSeq; XP_019651262.1; XM_019795703.1.
DR RefSeq; XP_019651263.1; XM_019795704.1.
DR AlphaFoldDB; G1LPH2; -.
DR STRING; 9646.ENSAMEP00000008952; -.
DR Ensembl; ENSAMET00000009335.2; ENSAMEP00000008952.2; ENSAMEG00000008484.2.
DR GeneID; 100467146; -.
DR KEGG; aml:100467146; -.
DR CTD; 11200; -.
DR eggNOG; KOG0615; Eukaryota.
DR GeneTree; ENSGT00800000124190; -.
DR HOGENOM; CLU_000288_63_47_1; -.
DR OMA; MLCAVQY; -.
DR TreeFam; TF101082; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd22666; FHA_CHK2; 1.
DR CDD; cd14084; STKc_Chk2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR44167; OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED; 1.
DR PANTHER; PTHR44167:SF9; SERINE_THREONINE-PROTEIN KINASE CHK2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 114..176
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 221..487
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61090 MW; E05048082981D371 CRC64;
MSRETDGECQ QSHGSSACSQ PQGGFSQSQG ISSQTHGSSS QSQGTSSSTS TAPTSSQSSH
SSSGTLSSLD TVSTQELCSI PEDQEPEEPV PAPWARLWAL QDGFPNLECV NDNYWFGRDR
SCDYCFDEPL LKRTDKYRTY SKKHFRIFRE MGPKNSYIAY IEDHSGNGTF VNRELVGKGR
RLPLNNNSEI ALSVWSNKVF VFFDLTVDDQ SVYPKELRDQ YILSKTLGSG ACGEVKLAFE
RKTCKKVAIK IISKRKFAIG SESGADPPPN VETEIEILKK LDHPCIIKIK DFFDAEDYYI
VLELMEGGEL FDRVVGNKRL KEATCKLYFY QMLLAVQYLH ENGIIHRDLK PENVLLSSQK
EDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLNSF GTAGYNRAVD CWSLGVILFI
CLSGYPPFSE HKTQVSLKDQ ITSGKFNFIP EVWTEVSEKA LDLVKKLLIV DPKVRFTTEE
ALRHPWLQDE DMKRKFQKLL FEETKSTALP QLPAQPSTSR KRRLEGEAED ADTTKRLAVC
AAVS
//
