ID G1LQB6_AILME Unreviewed; 1250 AA.
AC G1LQB6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=BRCA1 interacting protein C-terminal helicase 1 {ECO:0000313|Ensembl:ENSAMEP00000009247.2};
GN Name=BRIP1 {ECO:0000313|Ensembl:ENSAMEP00000009247.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009247.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009247.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009247.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002924394.2; XM_002924348.3.
DR AlphaFoldDB; G1LQB6; -.
DR STRING; 9646.ENSAMEP00000009247; -.
DR Ensembl; ENSAMET00000009645.2; ENSAMEP00000009247.2; ENSAMEG00000008785.2.
DR GeneID; 100465678; -.
DR KEGG; aml:100465678; -.
DR CTD; 83990; -.
DR eggNOG; KOG1132; Eukaryota.
DR GeneTree; ENSGT00950000182970; -.
DR HOGENOM; CLU_006515_1_0_1; -.
DR InParanoid; G1LQB6; -.
DR TreeFam; TF329449; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0070532; C:BRCA1-B complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0051026; P:chiasma assembly; IEA:Ensembl.
DR GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; IEA:Ensembl.
DR GO; GO:0010705; P:meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; IEA:Ensembl.
DR GO; GO:0106300; P:protein-DNA covalent cross-linking repair; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0007284; P:spermatogonial cell division; IEA:Ensembl.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 12..443
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 103..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1250 AA; 140493 MW; 8F6BDD2BDCF837DD CRC64;
MMSSLWSEYT IGGVKITFPY KAYPSQLAMM NSIVRGLNSK QHCLLESPTG SGKSLALLCS
ALAWQQSLSG KPVDESLSKK AEVPSSCCCA CHSKNFANTD LNQGTSHHFN SPSTPPSERN
DTSSTCQDSP EKTTLAAKLS AKKQASIKRD ENDDFQVEKK RIRPLETTQQ IRKRHCFEKE
VHHLDAKFAP GKTTKLNSPL GKKNSFSPQN PPGPCSRCCC STKQGSSQDS SNTTKKDHGG
KSKIPKIYFG TRTHKQIAQI TRELRRTAYS GVPMTILSSR DHTCVHPEVV GNFNRNEKCM
ELLDGKNGKS CYFYHGVHKI SDQHTLQTLQ GMCKAWDIEE LVSLGKKLKA CPYYTARELI
EDAHIIFCPY NYLLDAQIRE SMDINLKEQI VILDEAHNIE DCARESASYS VTEVQLRFAR
DELDSMVNNN IRKKDHEPLR AVCYSLINWL EANSEHLVER DYESSCKIWS GSEMLLNLHK
MGITTATFPI LQGHFSAVLQ KEEKVLPIHG KEESRIVPII SASTQIMLKG LFMVFDYLFR
QNSRFADDYK VAIQQTYSWI NQIDTSDKNG FFALAKNKKR SRQKTAVHVL NFWCLNPAVA
FSDISGKVWT IVLTSGTLSP MKSFSSELGV TFTIQLEANH VINNSQVWVG TIGSGPKGRN
LCATFQHTET FEFQDEVGEL LLSVCQTVSQ GILCFLPSYK LLEKLKERWL DTGLWDNLEL
VKTVIVEPQG GEKTDFDELL QVYYDAIKYK GEKDGALLVA VCRGKVSEGL DFSDDNARAV
ITIGIPFPNV KDLQVELKRQ YNDQHSKLRG LLPGRQWYEI QAYRALNQAL GRCIRHKNDW
GALILVDDRF RSNPSRYISG LSKWVRQQIQ HHSTFESALE SLTEFSKKHQ KVIGVSKADR
KFIQDSESTL EVTCLKDNLT YLSEAASLLA PENPRKGEAK MCVQERQCPT ITKSPSLPRG
IISRKERDDP VLLEESAQAV KAEKIVISRS TSPTFNKQTK RTSWSSFNSL GHYLTGEILT
ATPKFRSPED CASSVSTFET EKGCKTVLPL TDKCESSSLT VNSSFGPCAQ SEITISSIKI
DSNLLKINDS KQLLCCEEAL DPDIELSLVG EEAELSTSHR ASETEAEDES IYFSPELYDP
MDTNEEKNEL VESDRDSRLA NHSNCILVED LFEIRTMKGV DSVQEMKAED CTDTKLNRLM
HIKESKIGNI RSNVKTTHIN ESELGKTCET DKKNFKQSPS KNKGVFPGVK
//
