ID G1LQQ9_AILME Unreviewed; 236 AA.
AC G1LQQ9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=exodeoxyribonuclease III {ECO:0000256|ARBA:ARBA00012115};
DE EC=3.1.11.2 {ECO:0000256|ARBA:ARBA00012115};
GN Name=TREX2 {ECO:0000313|Ensembl:ENSAMEP00000009393.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009393.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009393.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009393.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.11.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000493};
CC -!- SIMILARITY: Belongs to the exonuclease superfamily. TREX family.
CC {ECO:0000256|ARBA:ARBA00025769}.
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DR RefSeq; XP_019665328.1; XM_019809769.1.
DR AlphaFoldDB; G1LQQ9; -.
DR STRING; 9646.ENSAMEP00000009393; -.
DR Ensembl; ENSAMET00000009793.2; ENSAMEP00000009393.2; ENSAMEG00000008933.2.
DR GeneID; 100477261; -.
DR KEGG; aml:100477261; -.
DR CTD; 11219; -.
DR eggNOG; KOG4793; Eukaryota.
DR GeneTree; ENSGT00390000012715; -.
DR HOGENOM; CLU_067419_1_0_1; -.
DR InParanoid; G1LQQ9; -.
DR TreeFam; TF323333; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR CDD; cd06136; TREX1_2; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR040393; TREX1/2.
DR PANTHER; PTHR13058; THREE PRIME REPAIR EXONUCLEASE 1, 2; 1.
DR PANTHER; PTHR13058:SF24; THREE PRIME REPAIR EXONUCLEASE 2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 9..210
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 236 AA; 25935 MW; 1B5AD6D490472242 CRC64;
MSEVPRAETF VFLDLEATGL PSIDPEVAEI SLFAVHRSSL ENPDQDESGA PVLPRVLDKL
TLCMSPERPF TAKASEITGL SSDSLARCRK AGFDNAVVRT LEAFLSRQEG PICLVAHNGF
DYDFPLLCTE LRRLGAHLPP DTICLDTLPA LRSLDRAHSH GTRAQGCKGY SLGSLFRRYF
QAEPSAAHSA EGDVHTLLMV FLHRAAELLG WADEQARSWA HIEPMYVPPD GPRLEA
//
