ID G1LTH6_AILME Unreviewed; 354 AA.
AC G1LTH6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Hematopoietic SH2 domain containing {ECO:0000313|Ensembl:ENSAMEP00000010373.2};
GN Name=HSH2D {ECO:0000313|Ensembl:ENSAMEP00000010373.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010373.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000010373.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000010373.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1LTH6; -.
DR STRING; 9646.ENSAMEP00000010373; -.
DR Ensembl; ENSAMET00000010825.2; ENSAMEP00000010373.2; ENSAMEG00000009875.2.
DR eggNOG; ENOG502RZYN; Eukaryota.
DR GeneTree; ENSGT00940000161678; -.
DR HOGENOM; CLU_067582_0_0_1; -.
DR InParanoid; G1LTH6; -.
DR TreeFam; TF336893; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14388:SF3; HEMATOPOIETIC SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14388; T CELL-SPECIFIC ADAPTER PROTEIN TSAD; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 34..125
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 152..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 39279 MW; 0BBF0F8ADB8278C5 CRC64;
MTEAGRLPPP LPPRLDWFVQ TQVAQLAQEG VPAWFHGAIS REDAKNLLQL RPPGSFLIRV
SHSHVGYTLS YKAQSCCRHF MVKLLDDGSF VIPGEEKAHA SLDALVTFHQ QQPVRPHGDL
LTQPCGQKDP ANSDYEDLFL YSSALTEEVA SPAYIPKEHQ NPSYYPRAAP QETSASPKGR
KPQGEMDRAS TEEATSSWPP KAPLEKACRK LWRNLKALPQ TGKRVQQQLT SHLTSTNLSS
LWNAGPPVVT HGPGARPGDT HWEDNVDTGR SVATSLASPS QPQDLRDRTD PSRRVSRLAS
WSEATPRVKD WPQAVVRALS SKVSKPETKD LAEPQKDWLP EEYRPPPPFA PGYC
//
