ID G1LUA8_AILME Unreviewed; 564 AA.
AC G1LUA8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=TNF receptor superfamily member 8 {ECO:0000313|Ensembl:ENSAMEP00000010656.2};
GN Name=TNFRSF8 {ECO:0000313|Ensembl:ENSAMEP00000010656.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010656.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000010656.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000010656.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1LUA8; -.
DR STRING; 9646.ENSAMEP00000010656; -.
DR Ensembl; ENSAMET00000011116.2; ENSAMEP00000010656.2; ENSAMEG00000010132.2.
DR eggNOG; ENOG502SNQ9; Eukaryota.
DR GeneTree; ENSGT00510000049215; -.
DR HOGENOM; CLU_043282_0_0_1; -.
DR InParanoid; G1LUA8; -.
DR TreeFam; TF331157; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0032759; P:positive regulation of TRAIL production; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13409; TNFRSF8; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020416; TNFR_8.
DR InterPro; IPR034002; TNFRSF8_N.
DR PANTHER; PTHR47497; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8; 1.
DR PANTHER; PTHR47497:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01923; TNFACTORR8.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..106
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 64..106
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 202..239
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 202..239
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 88..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 218..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 221..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 564 AA; 59574 MW; 7DF18578152C5B28 CRC64;
MTRKVSKGLT SQQPCARGPS DCGKQCEPDY YLDGDGRCKA CVTCAGDELV EKVPCAGNAS
RVCECRPGMF CVTSAINSCA RCEPHSTCAP GMVVQFRGTA ERDTVCEAPS PVTSPDCSTN
PEACQAPTST TPRAGPLGSS SASSRARTRT MLLGGGASLA PEDDSTMMRA PSSPSSVRKP
SPDPGPTSQQ PCAQGPSDCG KQCEPDYYRD GDGRCKACVT CSGDLVEKTP CTWNSSRVCE
CRAGMFCATS ATNSCARCNP HSACPPGMVT KAQGAVERDA TGESPPPEAR PECSTNPEDS
KAPTSATAPL VSSADPQISK EHGGGITHAW GDTPISTSTP ISFSSTGKPV LDSGSVLFWT
VLVLVMVLGS VSFLLCHRRA CRKWIQQKLH LCYPVQTFRP KLEPVDSRPR RNLTQLKSIS
VVESGMGELG LMSPPAVETP PNGAACLESM RLLEASPPAA GSPSSPRDLP EPRVTSEHTN
NRIEKIYIMK ADTVIVGTVR TEVPEGRGLA GPAGPEFEED LEVDHAPRFP EQETEPPLGS
CGDVMFSVEE EGKEAPLPMT VSEK
//
