ID G1LV71_AILME Unreviewed; 4313 AA.
AC G1LV71;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN Name=DYNC2H1 {ECO:0000313|Ensembl:ENSAMEP00000010972.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010972.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000010972.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000010972.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 9646.ENSAMEP00000010972; -.
DR Ensembl; ENSAMET00000011439.2; ENSAMEP00000010972.2; ENSAMEG00000010320.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154620; -.
DR InParanoid; G1LV71; -.
DR TreeFam; TF315251; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 200..652
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1119..1517
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1650..1985
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2120..2215
FT /note="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase"
FT /evidence="ECO:0000259|Pfam:PF21264"
FT DOMAIN 2624..2880
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2896..3227
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3252..3474
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3727..3835
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3868..4007
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4023..4310
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2896..2976
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3105..3195
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4313 AA; 492190 MW; F68BA78B14E057F5 CRC64;
MAGVSGDVRK VFIFTTTQNY FGLVSEPWDQ PLMYSCPEVN NFLDDGNQML LRVQRTDAGV
SFSSAIDFAD TKDKVLVFFK LRPEVITDQN LHNNILVSSM LESPINSLYQ AVRQVFAPML
LKDQEWSRNF DPKLQNLLSE LETGLGIVLR GSDTNSSKLN LKEDDTRGIL TPSDEFQFWA
EQAHRGNKQS SKERASYFKE LFETIAREFY NLDGLSLLEV VDLVETTRDV VDDVWRQTEH
DHYPESRMLH LLDIIGGSFG RFVQKKLGTL SLWEDPYYLV KDHLKAGISI CEQWVIACNH
LTGQMWQRYV PHPWKNEKYF PETLDKFGKR LEEVLAVRTI HEKLLYFLPA GEEKIMCLTR
IFEPFSGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLFQA
FLKYKELVKR PTISKELMLE RETLLARLVD SVKDFRLDFE NRCRGVPGEA SGPLAGKNLS
EVVNNIVWVR QLELKVDDTI KIAEALLSDL SGFRSFHRSA EDLLEQFKLY EQEQFDDWSR
DIQSGLSDSR SGLCIEANSR IMELDPNDGS LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK
SQITWDNPKE LEGYIQKLQN AAQRLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD
GLQELRTGLA SVAQGFQASD MRAWRQHWNH QLYKALEHQY QMGLEALNEN LPEISVDLTY
RQGRLQFRPP FEEIRAKYYR EMKRFIGIPN QFKGVAEAGE ESVFSVMIDR NASGFLTIFS
KAEDLFRRLS AVLQQHKEWI VIGQVDMEAL VEKHLSTVHD WERNFKALKI KGKEVERLPS
AVKVDCLNIN CNPVKTVIDD LIQKLFDILV LSLKKSIQAH LHKIDTFVTE AMEVLTVMPQ
SVEEIGDANL KYSKLQEWKP EILPLFQEAE DKNRLLRTVA GGGLETISNL KAKWDKFELM
MESHQLMIRD QIEVMKGNVK SCLQIYYQEL EKFKARWDQL KPGDDIIETG QQNALDASAK
SIKEKKIEFD DLEVIRKKLV DDCHHFGLEE PNFSLAYSIS KDLESCAQVW ALYEEFQQGL
QEMAGEDWIT FRTKTYLLEE FLMTWHDRLR KVEEHSAMTV KLQSEVDRYR TVIPILKYVR
GEHLSPDHWL DLFRLLGLPR GTSLEKLLFG DLLRVADEIV AKASDLKDLN SRAQGEVTIR
EALRELDLWG VGAVFTLTDY EDSQSRTIKL IKDWKDIVNQ VGDNRCLLQS LKDSPYYKGF
EDKVSIWERK LAELDEYLQN LNHIQRKWVY LEPIFGRGAL PKEQMRFNRV DEDFRSIMAD
IKKDSRVTTL TTHAGIRNSL LTILDQLQRC QKSLNEFLEE KRSAFPRFYF LGDEDLLEVL
GQSTSPSVIQ SHLKKLFAGI NSVCFDEETK HIIAMKSLEG EVVPFKNKVL LSNNVETWLN
DLALEMKQTL KQLLIECVTA GRSCQGSIDP SLFPSQILCL AEQIKFTEDV ENAIKDRSLH
HIETQLVTKL EHYTSTDTSS EDPGNTESGI LELKLKALIL DIIHNIDVVK QLNQVQVHTT
EDWAWKKQVR FYMKSDHTCY MQMVDSELQY TYEYQGNAPK LVYTPLTDKC FLTLTQAVKM
GLGGNPYGPA GTGKTESVKA LGGLLGRQVL VFNCDEGIDV KSMGRIFVGL VKCGAWGCFD
EFNRLEESVL SAVSMQIQTI QDALKNHRTV CELLGKEVEI NSNSGIFITM NPAGKGYGGR
QKLPDNLKQL FRPVAMSHPD NELIAEVILY SEGFKDAKVL GRKLVAIFNL SRELLTPQQH
YDWGLRALKT VLRGSGGLLR QLKTSGIKQN VDESHIVVQA LRLNTMSKFT FADCSRFDAL
IKDVFPGMDF KEVEYGELSS ALQQVFEEAN YEIIPNQIKK ALELYEQLRQ RMGVVIVGPS
GAGKSTLWRM LRAALCRIGR VVKQYTMNPK AMPRRQLLGH IDMDTREWSD GVLTNSARQV
VREPQDVSSW IICDGDIDPE WIESLNSVLD DNRLLTMPSG ERIQFGPNVH FVFETHDLSC
ASPATVSRMG MIFLSDEETD VNSLIKSWLK NQPPNYRNNL ENWIGDYFEK ALQWVLKQND
YVVETSLVGT VMNGLSHLCG SQNHDQFIIN LIRGLGGNLN MKSRLEFTKE VFNWARQSPP
DPHKPMDTYY DSSRGRLASY VLKKPENLTA DDFSNGQTLP VIQIPDMQRG LDYFKPWLNS
DTKQPFILVG PEGCGKGMLL RYAFAQLRST QTATVHCSAQ TTSRHVLQKL SQTCMVISTN
TGRVYRPKDC ERLVLYLKDI NLPKLDKWGT STLVAFLQQV LTYQGFYDEN LEWVGLENIQ
IVASMSAGGR LGRHKLTTRF TSIVRLCAVD YPEREQLQTI YGAYLEPVLQ KNLKNHSIWG
SSSKIYLLAG SMVQVYEQVR AKFTVDDHSH YFFTPCVLTQ WVLGLFRYDL EGGTSNHPLD
YVLEIVAYEA QRLFRDKIVG AKELHLFDSI LASVFQGDWG SDVLDNMADS FYVTWGARHS
SGTRAAPGQP LPPHGKPLGK LNSADLKDVI RKGLIHYGRD NQNLDILLFQ EVLEYMSRID
RVLSFPGGSL LLAGRSGVGR RTITSLVSHM HGAVLFSPKI SRGYELKQFK NDLKHVLHLA
GVEARQVVLL LEDYQFVHAA FLEMINSLLS SGEVPGLYTL EELEPLLLPL KDEASQDGFF
GPVFNYFTYR IQQNLHIVLI MDSANLNFII NCESNPALHK KCQVLWMEGW SDSSMRKIPE
MLFSDTDGKE KYNDKKRKEE RKKNSVDPDF LKSFLLIHES CKAYGATPSR YMTFLRVYSA
ISSSKKNELL KRQSHLQAGV SKLNEAKALV DELNRKAGEQ SVLLKIKQDE ADAALQEITV
SMQDASEQKT ELERLKHKIA EEVVKIEERK NKIDDELKEV QPLVNEAKLA VGNIKPESLS
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD ARNIPKEIRE
SVEELLYKNK GSFDSKNAKR ASTAAAPLAA WVKANVQYSH VLERIQPLET EQAGLESNLK
KTEDRKKKLE ELLNSVGQKV SELKEKFQSR TSEAAKLEAE VSRAQETVQA AKVLLGQLDR
EHKRWRVQVA EITEELATLP KRAQLAAAFI TYLSAAPEDL RKTCLEEWTK SACLEKFDIR
RFLCTESEQL IWKSEGLPSD DLSIENAVVI LQIIGLKSWS QVCPFLIDPS SQATEWLKTH
LKDSRLEVIN QQDSNFITAL ELAVRFGKTL VIQEMDGVEP VLYPLLRRDL VAQGPRYVVQ
IGDKIIDYNE EFRLFLSTRN PNPFIPPDAA SIITEVNFTT TRSGLRGQLL ALTIQHEKPD
LEEQKTKLLQ QEEDKKIQLA KLEESLLETL ATSQGNILEN KDLIESLNQT KASSALTQES
LKESHKLQIS LDQERDAYLP LAESASKMYF IISDLSKINN MYRFSLAAFL RLFQRALQNK
QDSENTEQRI QSLISSLKHM VYEYICRCLF KADQLMFALH FVRGMHPELF QENEWDTFTG
VVVGDMLRKA DSQQRIRDQL PSWIDQERSW AVATLKIALP SLYQTLCFDD VALWRTYYHS
SVCEQEFPSI LAKKVSLFQQ VLVVQALRPD RLQSAMALFA CRALGLKELS PLPLNLKRLY
KETLEIEPIL IIISPGADPS QELQELANAE RSGECYHQVA MGQGQADLAI QMLKECARSG
DWLCLKNLHL VVSWLPVLEK ELNTLQPKET FRLWLTAEVH PHFTPILLQS SLKITYESPP
GLKKNLMRTY ESWTPEQISK KDNIHRAHAL FSFAWFHAAC QERRNYIPQG WTKFYEFSLS
DLRAGYSIID RLFDGTKDVQ WEFLHGLLEN AIYGGRIDNY FDLRVLQSYL KQFFNSSIID
VLNQRNKKSV FPYSLSLPKS CSILDYRAVI EKLPEDDRPS FFGLPANIAR SSQRIISSQV
ISQLKVLGRS AAAGCKFDRE IWSNELSPVL NLWKKLNQNS NLIHQKVSPP NDRPGSPILS
FIILEQFNAI RLVQSIHQSL AALSKVIRGT TLLSSEVQKL ASALLNQKCP LAWQSKWEGP
EDPLQYLRGL VARALAIQSW VERAEKQALL SDTLDLSELF HPDTFLNALR QETARVMGCS
VDSLKFVASW EGRLQEATLQ IKMGGLFLEG CSFDGSQLSE NHHDSPSVCP VPPCCVGWVP
QGAYGPYSPN ECISLPVYTS AERDRVVANI DVPCGGNQDQ WIQCGAALFL KNA
//
