ID G1LVR9_AILME Unreviewed; 833 AA.
AC G1LVR9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN Name=MCM8 {ECO:0000313|Ensembl:ENSAMEP00000011170.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011170.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011170.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011170.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR RefSeq; XP_011230332.1; XM_011232030.2.
DR AlphaFoldDB; G1LVR9; -.
DR STRING; 9646.ENSAMEP00000011170; -.
DR Ensembl; ENSAMET00000011649.2; ENSAMEP00000011170.2; ENSAMEG00000010605.2.
DR GeneID; 100466603; -.
DR KEGG; aml:100466603; -.
DR CTD; 84515; -.
DR eggNOG; KOG0480; Eukaryota.
DR GeneTree; ENSGT01090000260080; -.
DR HOGENOM; CLU_000995_7_2_1; -.
DR TreeFam; TF323155; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 395..602
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 16..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 93059 MW; A38D89509767FF4E CRC64;
MNGDYRGRGF GRGRFQSWKR GRGGGSFTGK WRERERRPDL NKTTRKHTSE QTPQSLLLQS
TLDQLIPYKG WKLYFSEVYS SSSPFIQKIQ AFENFFTRRI DLYDKDEIER KGSIVVDFKE
LTEDDEMADL VPNLANELRD TPEKTLACMG LAVHQVLTRD LERHAAELQA QEGLSRDGET
MVNVPHIHAR VYNYEPLTQL KNVRANYYGK YIALRGTVVR VSNIKPLCTK MAFLCAACGE
VQGFSLPDGK YNLPTKCPVP TCRGRSFTAL RSSPLTVTMD WQSIKIQELM SDDQREAGRI
PRTIECELVH DLVDSCVPGD TVTITGVVKV SNAEEGSRNK NDKCMFLLYI EANSVSNSKG
QKTKTSEDGC KHGALMEFSL KDLYAIQEIQ AEENLFKLIV NSLCPVIFGH ELVKAGLALA
LFGGSQKYAD DKNRIPIRGD PHVLVVGDPG LGKSQMLQAV CNVAPRGVYV CGNTTTTSGL
TVTLSKDSSS GDFALEAGAL VLGDQGICGI DEFDKMGNQH QALLEAMEQQ SISLAKAGMV
CSLPARTSII AAANPVGGHY NKAKTVSENL KMGSALLSRF DLVFILLDTP DEDHDHLLSE
HVIAIRAGKQ RAVSSATIAR MNSQDSNTSV LEVVSDKPLS ERLKVVRGET IDLIPHQLLR
KYIGYARQYV YPRLSTEAAQ ILQDFYLELR KQSQRLNSSP ITTRQLESLI RLTEARARLE
LREEATKEDA EDIVEVMKYS MLGTYSDEFG NLDFERSQHG SGMSNRSTAK RFISALNNIA
ERTYNNLFQF QQLRQIAKEL NIQVADFENF IGSLNDQGYL LKKGPKVYQL QTM
//
