ID G1LVY7_AILME Unreviewed; 1059 AA.
AC G1LVY7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSAMEP00000011238.2};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSAMEP00000011238.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011238.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011238.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011238.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011230245.1; XM_011231943.2.
DR AlphaFoldDB; G1LVY7; -.
DR STRING; 9646.ENSAMEP00000011238; -.
DR Ensembl; ENSAMET00000011717.2; ENSAMEP00000011238.2; ENSAMEG00000010676.2.
DR GeneID; 100475994; -.
DR CTD; 197358; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000159861; -.
DR HOGENOM; CLU_002274_3_0_1; -.
DR InParanoid; G1LVY7; -.
DR TreeFam; TF329403; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF13516; LRR_6; 12.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 14.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 133..264
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 113998 MW; 26661906B9BA3C12 CRC64;
MRKQEVRTGG ETGQGRGPGS PAGQVKVLVD LLAGKSNQSS QTPQTPDRMP HGDDSRIQKC
QEALLNRVKG SPELGGPSPR LTNLLLVEGL TDLQLKEHDF TQVETTRGGW HPARIIALER
LFLPLSRVSI PPRISITIGV AGVGKTTLVR NFVHLWARGQ VGKDFSLLLP LTFRDLNTYE
KLSADRLIRS VFPHIGESGL AAAALPQTLL ILDGLDECKT PLDFSNTAAC TDPKKEIQVD
HLITNIIRGN LFPEVSVWVT SRPGVAGQIP GGLVDRMTEI RGFNEEEIKV CLEEMFPEDH
TLSDWVLRQV QADRALYLMC TVPAFCRLAG SALGHLSRTK PGPQDSALWT PRTLCELYSW
YFRMALGGDG QEKGKASPRI EQVAHSSRKM VGTLGRLAFH GLVRRKYVFY EQDLKAFGMD
LAVLQSALCG CFLRREETLA SSTAYCFSHL SLQEFVAAAY YYSASKRAIF DLFTEGGVSW
PRLGFLTHFR SAAQRAMQAE DGRLDVFLRF LSGLLSPRVN ALLAGSLLAQ GEHQGYRAQV
AELLQGCLRP DVAVCARAVN TLHCLHELQH TELACSVEEA MRSGGLAGLT SPQHRAALAY
LLQVSDACAQ EANLSLCLSK GVLQSLLPQL LYCRSLRLDN NQFQDPVMDL LGSVLSGKDC
RIQRISLAEN QIGNKGAKAL ARSLLVNRSL TALDLRSNSI GPQGAKALAD ALKINRTLAF
LSLQSNAIRD NGARSVAEAL AANRTLSVLH LQKNTIGPVG AQRMADTLKQ NRSLKELIFS
SNSIGDGGAE ALAMALKVNQ GLESLDLQSN SISDAGVAAL MGALCANQTL ISLNLRENSI
SSEGARELAR ALCINCTLKN LDLTANLLQD QGAQAIAVAM RENQALTSLH LQWNFIQAGA
AKALGQALQL NRSLTSLDLQ ENAIGDEGAS AVASALKANT ALTALYLQVA SIGSRGAQAL
GDALAVNKTL EILDLRGNTI GAAGAKALAN ALKVNSSLRR LNLQENSLGM DGAICVATAL
SGNHSLQHIN LQGNHIGESG ARMISEAIRT NAPSCTVEM
//
