ID G1LW85_AILME Unreviewed; 2170 AA.
AC G1LW85;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Dedicator of cytokinesis 6 {ECO:0000313|Ensembl:ENSAMEP00000011336.2};
GN Name=DOCK6 {ECO:0000313|Ensembl:ENSAMEP00000011336.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011336.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011336.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011336.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9646.ENSAMEP00000011336; -.
DR Ensembl; ENSAMET00000011819.2; ENSAMEP00000011336.2; ENSAMEG00000010680.2.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000159313; -.
DR HOGENOM; CLU_000624_0_0_1; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF65; DEDICATOR OF CYTOKINESIS PROTEIN 6; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 636..802
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1710..2146
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 107..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2170 AA; 242137 MW; A6302DC50461F6D9 CRC64;
MPCPSKSFHL CLAGAGGWGV GRAPRPSFGG WSWGLCISHN PGALMLRFVL SEARVLLVRG
LGFSLAQPGF SSRRMNFLGR SGVPRAPLPE LSCPQWPLPC PRRTVAAEVR KQVSRERSGS
PHSSRRSSSS LGVPLTEVIE PLDFEDVLLS RPPDAEPGPL RDLAEFPADD LELLLQPREC
RTTEPGIPED GKLDAQVRAA VEMYTEDWII AHRRYQHLSA AYSPITTETQ RERQKGLTRQ
VFEQDASGDE RSGPEDSDDP RHSSGSPDDT PRSSGASSIF DLRNLAADSL LPSLLERTAP
EDVDRRNEAS RRQNRPRALL ALYPAPDEDE AVERCSRPEP PREHFGQRIL VKCLSLKFEI
EIEPIFGILA LYDVREKKKI SENFYFDLNS DSMKGLLRAH GTHPAISTLA RSAIFSVTYP
SPDIFLVIKL EKVLQQGDIS ECCEPYMVMK EVDAAKNKEK LEKLRLAAEQ FCTRLGRYRM
PFAWTAVHLA NIVSSAGQPD RDSDSEGERR PAWTDRRRRG PQDRTSSGDD TCSFSGFRPA
TLTVTNFFKQ EAERLSDEDL FKFLADMRRP SSLLRRLRPV TAQLKIDISP APENPHFCLS
PELLHVKPYP DPRGRPTKEI LEFPAREVYA PHTSYRNLLY VYPHCLNFSS RQGSVRNLTV
RVQYMAGEDP SQALPVIFGK SSCSEFTREA FTPVVYHSKS PEFYEEFKLR LPACVTENHH
LLFTFYHVSC QPRPGTALET PVGFTWIPLL QHGRLRTGPF CLPVSVDQLP PSYSVLTPDV
ALPGMRWVDG HKGVFSVELT AVSSVHPQDP YLDKFFTLVH VLEEGAFPFR LKDTVLSEST
VEQELRASLA ALRLASPEPL VAFSHHVLDK LVRLVVRPPI IGGQIVNLGR GAFEAMAHVV
SLVHRSLEAA QDARGHCLLL AAYVQYAFRL PGTEPSLPSG APPVAVQPAT LARGPGRPAS
LYLARSKSIS SSNPDLAVAP GSVDDEVSRI LASKGIDRSH SWVNSAYAPG GSKAVLRRAP
AYCGADPRQL LHEELALQWV VSGSAVREAV LQHAWFFFQL MVKSMALHLL LGQRLDTPRK
LRFPGRFLDD IAALVGSVGL EVITRVYKDA ELAERLNASL AFFLSDLLSL VDRGFIFSLV
RAHYKQVATR LQSAPNPALL LTLRMDFTRI LCSHEHYVTL NLPCCPLSPP ASPSPSVSST
TSQSSTFSSQ APDPKVTSMF ELSGPFRQQH FLAGLLLTEL ALALEPEAEG ASLLHKKAIS
AVHSLLCGHD ADPRYAEAAV KARVAELYLP LLSLARDTLP RLHDFAEGPG QRSRLASMLD
SDTEGEGDIG GTINPSVAMA IAGGPLAPGS RASISQGPVA ASRSGCPLSA ESSRTLLVCV
LWVLKNAEPA LLQRWAADLA LAQLGRLLDL LYLCLAAFEY KGKKAFERIN SLTFKKSLDM
KARLEEAILG TIGARQEMVR RSRERSPFGN QENVRWRKSV THWRQTSDRV DKTKDEMEHE
ALVDGNLATE ASLVVLDTLE IIVQTVMLSE ARESILGAVL KVVLYSLGSA QSALFLQHGL
ATQRALVSKF PELLFEEDTE LCADLCLRLL RHCGSRVSTI RTHASASLYL LMRQNFEIGN
NFARVKMQVT MSLSSLVGTT QSFSEEHLRR SLKTILTYAE EDVGLRDSTF AEQVQDLMFN
LHMILTDTVK MKEHQEDPEM LIDLMYRIAR GYQGSPDLRL TWLQNMAGKH AELGNHAEAA
QCMVHAAALV AEYLALLEDS RYLPVGCVSF QNISSNVLEE SAISDDILSP DEEGFCSGKH
FTELGLVGLL EQAAAYFTMG GLYEAVNEVY KTLIPILEAH RDYKKLAAVH GKLQEAFTKI
MHQSSGWERV FGTYFRVGFY GARFGDLDEQ EFVYKEPSIT KLAEISHRLE EFYTERFGED
VVEIVKDSNP VDKTKLDPQK AYIQITYVEP HFDTYELKDR VTYFDRNYGL RTFLFCTPFT
PDGRAHGELP EQHKRKTLLS TDHAFPYIKT RIRVCHREET VLTPVEVAIE DMQKKTRELA
FATEQDPPDA KMLQMVLQGS VGPTVNQGPL EVAQVFLAEI PEDPKLFRHH NKLRLCFKDF
CKKCEDALRK NKALIGPDQK EYHRELERNY GRLREALQPL LTQRLPQLLV PTTAGLRNSL
NRASFRKADL
//