ID G1LXD6_AILME Unreviewed; 1309 AA.
AC G1LXD6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSAMEP00000011739.2};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSAMEP00000011739.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011739.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011739.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011739.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 9646.ENSAMEP00000011739; -.
DR Ensembl; ENSAMET00000012237.2; ENSAMEP00000011739.2; ENSAMEG00000011143.2.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; G1LXD6; -.
DR TreeFam; TF331379; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1309
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030171145"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 28..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 463..490
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 48..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1309 AA; 147316 MW; 3AD5230D9965B7AF CRC64;
MGSAGAAGRA TWVLAWSLLA AALALPAGPG GRGWHPAGPG LLGRPLGGQP LPDPPAXXTL
PDPPAAPGAG PERSAQDLPH LIWPSLESSG FKTEVRAPFG RKFSRKNEVF KPLPTSAPST
GPGTQSSLAF TPSWPKKTLF KRESPITHGL FGDISRDVSG TAEDGVIFQK CAVVSGQSEL
QTAQVRLLVD NTRTPVATNL SDLLLLDNIT GLSVRESDGN QTSAGFQAFR KKFLQVGDSF
SVSYTASIKA GEVGSGEVLM LPAQLTFQSS AQNRTQLKAL FTITAEEKIK VVPNHGLHVA
GFFIASIVSF VLTWVTLFFL ARYQCLKGGL PTRHQVQHHE SKLEHSQFTS ADGVNEDLAL
NDQMIDILSS EDPGSMLQAL EELEIATLNR ADSDLEACRT QISRDIIALL LKNLASSGHL
SPQVERRMGA AFKKQFLWLE KEIQEEYDRK MVALTAECDL ETRKKTESQY QREMAAMEEA
EGLLKRVSER SAMECSSLLR TLHGLEQVHL RRSLALQQEE DFAKAHRQLA IFQRHELHNI
FFTQIKSAIF QGELKAEAAK MLLQDYADIQ EKLEELMDFF QASKRYHLSK RFGHREYLVQ
NMQSSETRVQ GLLSTADTQL TLFIQKHERA GYLDEEQMET LLERVQTEVF SIKQKLDNDL
KQEKKKLHQK LILKRRREML QKHKEQRKEQ LSLGEALRAA EDASQYLGRW GSLLAEHSAA
LEDLQERLDQ AALEELRALT LSLSEKATEE LRRLQNSGMT QELLKRGVPW LFLQQILEEH
SRELAARAQQ LEGEERDRDQ EGVQSVRQRL KDDALEASTE EQAELRRWEH LIFAKLCSSA
FSLSEEELLG MRQEVHGCFA QMDRSLALPK IRARVLLQQF QTAWREAELL RLDQALGAPE
LPQQPKVRKP RSKSKSKIDL LRKSIEDKIQ LFEEQAPEDL VEKVRGELLR ERVQQLEAQE
ARFAESLVSL QFQKVARMAK TLWAYTALLS VQDLLLEELR ESETLTKLAC EQILGSHSPE
LQELERKLED KLAHQETAQL QRALATRQQW AGDGPGLLGE PEDSGSERQI SAVLQQALSQ
GRKLLERHQQ SWREERDHNV VLEDLLENVE LDTFAALYSQ ELRLASYLSR LAMVPGGTLR
RLLSVALPTA SQSELLAALD PGSQKHPDHM VENDGGGEQA DMGRRRKHQG WWQALESRLR
GELISRGLEK MLWARERKES ILEKTCPPLR ERVAMPGKGS WPHLSLESIG EPAAVPIVGA
ETIDLLNTGE KLFIFRNPKE PEISLHPPPR RKKKNFLNAK KATWALGMD
//