ID G1LZ51_AILME Unreviewed; 1848 AA.
AC G1LZ51;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=TSPO associated protein 1 {ECO:0000313|Ensembl:ENSAMEP00000012359.2};
GN Name=TSPOAP1 {ECO:0000313|Ensembl:ENSAMEP00000012359.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012359.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012359.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012359.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR STRING; 9646.ENSAMEP00000012359; -.
DR Ensembl; ENSAMET00000012889.2; ENSAMEP00000012359.2; ENSAMEG00000011688.2.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_1_0_1; -.
DR InParanoid; G1LZ51; -.
DR TreeFam; TF316230; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0044305; C:calyx of Held; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0030156; F:benzodiazepine receptor binding; IEA:Ensembl.
DR GO; GO:0099626; F:voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234:SF20; PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 650..717
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 881..973
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1614..1682
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1755..1822
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1699..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1805..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 122..192
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 414..511
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 283..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1833..1848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1848 AA; 198765 MW; D1644C1D5E81F1D9 CRC64;
MEQLTPLPQL GDPRAMEPWA LPAWPSWTPG QGSEPGGATP SIADTPAALL GGEQRPEESS
EPEGAQSPGA TGGIDPEGTK TGLPSLRHQA ASSRPSCPRL DDEEVEAFPK GKLDMGFGDR
PNLELLRALG ELQQRCAVLK EENQMLRKSG FPETEEKVRR LKRKNAELAV IAKRLEERAR
KLQETNLKVV SAPVPRPGAG LELCRKALAH QRARDLSETA SALLAKDKQI AALQRECREL
QARLTLVGKE GPQWLHVRDF DRLLRESQRE VLRLQRQIAL RNQQEPPPPP RPPGPAAPVR
AGAPAPGAPG EATPQEDVEN PPAILGEPER QQRVQQLESE LSKKRKKCES LEQEARKKQR
RCEELELQLR EAQNENARLV EENSRLSGRA TEKEQVEWEN AELRGQLLGV TQERDSALRK
SQGLQSKLEG LEQVLKHMRE AAQRRRQLEV EHEQARLSLQ EKQEEVRRLQ QAQAEAKREH
EGAVQLLEST LDSMQVRVRE LEGQCRSQTE RFSLLAQELQ AFRLHPGPLD LLTSALGYST
LGEHPPPPCC CSTPQPCRGS GPKDLDLPPG SPGRCTPKSS EPAPATVTGV ARRTAKKAES
LSNSSRSESI HNSPKSCPTP EVDTASEVEE LEADSVSLLS AAPEGSRGGA RIQVFLARYS
YNPFEGPNEN PEAELPLTAG EYIYIHGNMD EDGFFEGELM DGRRGLVPSN FVERVSDDDL
LTSLPPELAD LSHSSGPELS FLSGGGGGSS SGGQSSGGRS QPGPEDEAAG NELSPSPQPE
GLGGPPAVPY PRSLVVLRQL AHSVVLAWEP PPERVELRGY HICVNGELRQ ALGPGVPPKA
VLENLDLRAG PLRISVQALT SQGSSDPLRC CLVVGTRAGV LPSQLRVHRL TATSAEITWV
PGNSNLVHAV YLNGEECPPA RPSTYWATFC HLRPGTLYQA RVEAQLPPPE SWDPGWERPE
QRAATLQFTT LPAGPPDAPL DVQIEPGPSP GILIISWLPV TIDAAGTSNG VRVTGYAVYA
DGQKIMEVAS PTAGSMLVEL SQLRLLQVCR EVAVRTMSPH GESADSIPAP VPPALVAACP
PATVSCPSPR PGSEARPPLA PASPGPGDPS SPLRRPDPCG TREPPGGPPA GETPKGSHEE
PPAPCAQEEA GAAVLGASED VKASEPSAAE RAPDPAASPL AKEEALPVPC SAQGALGRQV
PCAEGCRGGD PGSGLRPRAE REDTAELGGR LVNSLVDHGR NSDLSDIQEE EEDEEVELGS
RTCSFQKQVV DHSIRENGAK PQPDPFCETD SDEEILEQIL ELPLQQFCSK KLFSIPEEEE
EEDEEDEEQE EDEERPGAGC SFRDPGPPEP AALGLGCDSG QPRGPGPCPL SPEPCRAGDR
LEDMPGLAGG SSRRRGSGSP EKPPNRRRSP DPREHCSRLL SNGGPQASGR PGPTRERGSP
PVGEGTKGVP EAGGRGRPPP FRRCSRGRAP ESSLASCLSP KCLEISIEYD SEDELEAGSG
GISITSSCYL GDGEAWGTAP IGRSRGPLKA NSGPHPYPCL SAWEKGEPER RSRSATGRAK
EPPSRATETG EPREKDISGR RGPSRRGVQV PRACATELAP LRSPPEEALL YPDLPVRVFV
ALFDYDPVSM SPNPDAGEEE LPFREGQILK VFGDKDADGF YRGEGGSRMG YIPCNMVVEV
AVASPAERQQ LLQRGYLSPD VLTEGSGNGP SVSSTARTAG PPPKPRRSKK AEAESPAPAR
PCAGHLQHVP SAGLKSPRTM VAAFDYNPRE SSPNMDVEAE LPFRAGDIIT VFGDMDDDGF
YYGELNGQRG LVPSNFLEGP GPEASSSDRE PRTPQPESQR TRRRRVQC
//
