ID G1LZ78_AILME Unreviewed; 853 AA.
AC G1LZ78;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Thrombospondin type 1 domain containing 1 {ECO:0000313|Ensembl:ENSAMEP00000012386.1};
GN Name=THSD1 {ECO:0000313|Ensembl:ENSAMEP00000012386.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012386.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012386.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002917718.1; XM_002917672.3.
DR AlphaFoldDB; G1LZ78; -.
DR STRING; 9646.ENSAMEP00000012386; -.
DR Ensembl; ENSAMET00000012917.2; ENSAMEP00000012386.1; ENSAMEG00000011783.2.
DR eggNOG; ENOG502QY3P; Eukaryota.
DR GeneTree; ENSGT00390000013335; -.
DR HOGENOM; CLU_336470_0_0_1; -.
DR InParanoid; G1LZ78; -.
DR OMA; SHPRNSH; -.
DR OrthoDB; 5301340at2759; -.
DR TreeFam; TF333148; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR038877; THSD1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR16311; THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1; 1.
DR PANTHER; PTHR16311:SF3; THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..853
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003414307"
FT TRANSMEM 415..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 446..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 93467 MW; 6EF287AE94AFC039 CRC64;
MKRMLKDFSN LLLVVLCDYV LGEAEHLLLG KPGHVALSNS TVSVDFRHFG GANGALRNVS
ILLLEANTNR TVTTKYLLTN QSRGTLEFEC FYFREAGDYW FTMFLEAADN STPVRRGEQS
AFLKVDWPVF HIDLNRTSQA AEGTFQVGLF TNQPLCSFPA DQPDILVDVA FTNSLPEART
SPGPPLEIRT SKRTELSQGQ WVEFGCAPVG PEAYVTVVLK LLGRDSVITS TGPINLAQKF
GYKLVLAPEL TCESGVEVLV RPPPCIFVQG LITVFKEAPR RPGERTIQLA ENSLTLGERR
TVFNCTLFDM GRNKYCFDFG VSSRSHFSAK ERECMLIQRN IETWGLWQPW SQCSTTCGDG
VRERRRVCLT SFPSRPGCPG MSSETSLCSL EECAAFQPSS ASPLQPQGPV KSNNIVTVTG
ISLCLFIIVA TILITLWRKF GRAPKCSTPA RHNSIHSPSF RKNSDEENIC ELSEPRGSFS
DGGDGPAGGP GDAGIPLTYR RSVPLSPEDD ASGSESVQST AQKIIPPLFS YRLAQQQLKE
MKKKGLTETT KVYHVSQSPL TDTAIDAAAV PALDLEGPEE AAAGKFRIKA PFLEQPAGGA
APRPPSRLDL PACPASCAVS PSQTVIRKSA LRHVGGRGAL PERSHPRGSH FRRTASFHEA
KQARPFRERS MSTLTPRQAP AYGSRTRTWD QAEDRFRPQS RGAAPFPEKP DPFQGAGATR
GPLSPPPKSY TLGQPVRKPD LGDCQAGSTA GVERTEPHRA RRGPSPSHRS VSRKQPSPTV
PKDGYQRVSP LSPSQCRKDK CQSFPAHPEF AFYDNTSFGL TEAEQRMLDL PGYFGSNEED
ETTSTLSVEK LVI
//
