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Database: UniProt
Entry: G1LZJ8_AILME
LinkDB: G1LZJ8_AILME
Original site: G1LZJ8_AILME 
ID   G1LZJ8_AILME            Unreviewed;      2701 AA.
AC   G1LZJ8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSAMEP00000012506};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSAMEP00000012506};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012506, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000012506}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000012506}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; ACTA01057936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01065936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01073936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01081936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01089936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01097936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01105936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01113936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01121936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01129936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002917158.1; XM_002917112.3.
DR   STRING; 9646.ENSAMEP00000012506; -.
DR   Ensembl; ENSAMET00000013040; ENSAMEP00000012506; ENSAMEG00000011767.
DR   GeneID; 100477888; -.
DR   KEGG; aml:100477888; -.
DR   CTD; 3709; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; G1LZJ8; -.
DR   KO; K04959; -.
DR   OMA; ENQVKGG; -.
DR   OrthoDB; 94996at2759; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2228   2250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2262   2281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2302   2326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2346   2374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2395   2417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2522   2545       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED     1596   1616       {ECO:0000256|SAM:Coils}.
FT   COILED     1922   1942       {ECO:0000256|SAM:Coils}.
FT   COILED     2632   2680       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2701 AA;  307742 MW;  EF0CF84AE2C2E918 CRC64;
     MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNSSWKI TLFMKYSSYR EDVLKGGDVV
     RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
     SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDGDLPTS KKKRQAGEKI MYTLVSVPHG
     NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TSIPIDTDEE RPVMLKIGTC
     QTKEDKEAFA IVSVPLSEVR DLDFANDANK VLATTVKKLE NGTITQNERR FVTKLLEDLT
     FFVADVLNNG QEVLDVVISK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED
     LGDQRYAPYK YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NTTAIPVTQE LICKFMLSPG
     NADILIQTKL VSMQVDNPME SSILSDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAKEGT
     KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR
     LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE
     YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
     SSYFERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVQPSI HPSKQGSPVE
     PEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF GENNENSEAS ASGSPDTLLP
     SAIVPDIDEI AAQAETMFAG RKEKNPVQLD DEGGRTFLRV LIHLIMHDYP PLLSGALQLL
     FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSSYENGE
     MGESQVKGGE EPIEESSILS PVQDGTRKPQ IDSNKSNNYR IVKEILIRLS KLCVQNKKCR
     NQHQRLLKNM GAHSVVLDLL KIPYEKNDEK MNEVMNLAHT FLQNFCRGNP QNQVLLHKHL
     NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD
     GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLHMMC SERDRGDESG PLVYHITLVE
     LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE
     IYTSNHIWKL FENFLVDMAR VCSTTTDRKH ADTSLEKCVT ESIMSIVSGF FNSPFSDNST
     SLQTHQPVFI QLLQSAFRIY SCTWPNPAQK SSVESCIRTL AEVAKNRGIA IPVDLDSQVN
     TLFLKSHSNM VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM
     MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE
     MLEKKDSFVE EGNTLRKILL NRYFKGDYGV GMNGHLSGTY CKSAQGGGSF SGQDSDKMGI
     SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ
     KKSEKFFKVL YDRTKAAQKE IRSTVTVNTI DLGNKKRDDD NELMTSGPRM RVRDSSLLLK
     EGMKGQLTEA SSATSKAYYA YRREMDPEID IMCAGSEVGN AEENSAEEVA MSPAIAIMQP
     ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINEK
     NVVLVNQTLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL
     KNNASKLLLA IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DDEGGDDGVS
     PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPDDGDEALK YYANHTAQIE IVRHDRTMEQ
     IVFPVPNICE YLTRESKCRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRSNPALF
     WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PLFSVLLWIA VAVCTSMLFF
     FSKPVGIRPF LVSIMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV
     ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV
     LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPITGSNEV PTMTLTSTME TCQKDNCTPT
     IPASNTADEE YEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY
     DLLFYFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE
     EHIKSEHNMW HYLYFLVLVK VKDPTEYTGP ESYVAQMIVE KNLDWFPRMR AMSLVSNEGD
     SEQNEIRNLQ EKLESTMSLV KQLSAQLAEL KEQMTEQRKT KQRLGFLGSN TPHVNHHVPP
     H
//
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