ID G1LZM8_AILME Unreviewed; 2117 AA.
AC G1LZM8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Myosin VIIB {ECO:0000313|Ensembl:ENSAMEP00000012538.2};
GN Name=MYO7B {ECO:0000313|Ensembl:ENSAMEP00000012538.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012538.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012538.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012538.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 9646.ENSAMEP00000012538; -.
DR Ensembl; ENSAMET00000013072.2; ENSAMEP00000012538.2; ENSAMEG00000011843.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000157247; -.
DR HOGENOM; CLU_000192_14_1_1; -.
DR InParanoid; G1LZM8; -.
DR TreeFam; TF335306; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0090651; C:apical cytoplasm; IEA:Ensembl.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 65..760
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 989..1192
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1197..1508
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1502..1568
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1645..1794
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1800..2103
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 637..659
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1588..1609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 158..165
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2117 AA; 241302 MW; E7ECDB0AF1DE9D17 CRC64;
MSAFKLGDHV WLNPLSANKT SVAIGCIVKE TKPGKILVED DEGKEHWIRA EDLATLSPMH
PNSVQGVDDM IRLGDLNEAG MVHNLLTRYR QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ
LYCSHHMGEL PPHVFAIANN CYFNMKRNKR DQCCIISGES GAGKTETTKL ILQFLATVSG
QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIH FNPSGVIEGA RIEQFLLEKS
RVCRQAPEER NYHIFYCMLM GMAAEEKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH
VRSAMKILMI SDSEHWDLSK LLAAILHLGN VQFMAAVFEN LDSSDVMDSP AFPTVLKLME
VEYQALRDCL IKHSIIIRGE FVTRPLNITQ AADRRDAFVK GIYGHLFLWI VKKINTAIFT
PPGQDPKNVR RAIGLLDIFG FENFQNNSFE QLCINFANEH LQQFFVQHVF TMEQEEYLSE
NIAWDYIHYN DNRPTLDLLA LKPMSIISLL DEESRFPKGT DITMLQKLNN VHANNKAYLQ
PKNIHDARFG ITHFAGEVYY QTEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFKLESAGT
KLGHGTIIRA KAGSQHFKST DPSKQPSTLA GQFKKSLDQL MKILTGCQPY FIRCIKPNEY
KKPLLFDREL CIRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVVLPS AVRLQFLDKA
RQMTLRIAEM RLGTDKEWKV GKTKIFLKDN QDTLLEVQRS EALDKAAVNI QRVLRGYKWR
KEFLRQRRAA VTLQAGWRGY YNRRNFKQII LGFERLQAIA RSQLLAKQYQ IMRQRMVQLQ
ALCRGYLVRQ QVQAKKRAVV VIQAHARGMA ARRNFRQQKA NGPLVIPTEE QKSQTALPTR
KRKSIYDTIT DTEMVEQVFG FLPSMIGGQE GQAPQRFEDL EARTQKLPEV DLDTVPMVEE
SEDDTDSLDE YTFPKFAATY FQKSASHTHI RRPLRSPLLY HENDADCSAA LAVWSIILRF
MGDLPEPVLF AGNGLHGGSV TQQIHDTLGR ENSTQPPQHG ASTQVTSQLN IGEESFEPDG
PISDRPMSNL EKVQFIVGYA ILRRNLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC
FPPSERFMKY LLNFIGQGPA GYGPFCAERL KRTYANGVRT EPPTWLELQA VKSKKHIPIH
VALETGESLT VMVDSASTSR EVCQHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHVMD
AVAQCEQLAR ERGENERQAP WRIYFRKEFF TPWHDSQEDS VSTQLIYCQV MHGVRSGEYT
FEKEEELVQL LAQRCYVQHG ASVGSEAIRE LLHSCVPSKL YRTKPPEKWA SLVTAALAKA
QYTQKQAKPL AVQEQVVDAA RLQWPLLFSR LFEVTTLSGP RLPKTQLILA VNWKGIYFLD
QKEKMLLELS FPEVMSLITN REAQGGQRLV VSTLHEEEYE FMSPSSVAIA ELVAMFLEGL
KERSVFAMAL QDRKATDDTT LLPFKKGDLL ILTKKQGLLA SEHWTLGQND RTGKTGLVPT
ACLYAIPTVT KPSAQLLSLL AMSPEKRKLA AQEGRPTEPL PGEQPKDKPH TLEEFSYEFF
RAPEKETVSR AMFPLARTRG HLWAHSPEPL RQPLLKCVHA SAELRDLACQ IFIAILRYMG
DYPSRQAWTS VELTDQIFSL ALQDSALQDE VYCQILKQLT HNTKRYSEER GWQLLWLCTG
LFPPGKALLP HAQKFVDTRR KQLLAPDCSR RIQSILRTGP RKQPPHPMEV EAVEQNISRI
CHKIYLPNDT SEMLEVGTHT RVRDVCQSVA TRLQLASWEG CSLFIKIADK VISQKEGDFF
FDSLRQVSDW VKKNKPQKEG APVTLPYQVY FMRKLWLNVT PGKDVNADTI LHYHQELPKY
LRGFHKCSRE DAVHLAGLIY KAQFDNDRSQ LASIPKILRE LVPENLTRLM SSEEWKKNIL
LAYDKHKDKT VGEAKVAFLK WICRWPTFGS AFFEVKQTSE PSYPDIILIA INRHGVLLIH
PKTKEPLTTY PFTKISSWSS GSTYFHMALG SLARGSRLLC ETSLGYKMDD LLTSYVQQLL
SSVNKQRGSQ APALADP
//
