ID G1LZP6_AILME Unreviewed; 846 AA.
AC G1LZP6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Interacts with SUPT6H, CTD assembly factor 1 {ECO:0000313|Ensembl:ENSAMEP00000012556.2};
GN Name=IWS1 {ECO:0000313|Ensembl:ENSAMEP00000012556.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012556.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012556.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012556.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR RefSeq; XP_019663995.1; XM_019808436.1.
DR AlphaFoldDB; G1LZP6; -.
DR STRING; 9646.ENSAMEP00000012556; -.
DR Ensembl; ENSAMET00000013090.2; ENSAMEP00000012556.2; ENSAMEG00000011927.2.
DR eggNOG; KOG1793; Eukaryota.
DR GeneTree; ENSGT00720000108834; -.
DR HOGENOM; CLU_018182_0_0_1; -.
DR TreeFam; TF315504; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 642..720
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 95268 MW; 1BF7B5AF5FB147D1 CRC64;
MDSEYYSGDQ SDDGGATPVQ DERDSGSDVE DDVNEQHSGS DTGSVERHSE NEPSDREDGL
NKRHQVTDSE NDDPSNLNAS DSESEELQRQ KDSDSESEEH AEPRASDSEN EDTNQHGSDS
ESEETRKLPV SDSENEELLN GHASDSENED VRKHPASDSE VEVLPKSPAS DSETEDPLKP
QISDSESEEP PRHQASDSEN EELPKPRISD SESEELPKPR VSDSESEEPQ RTQASDSENE
ELPKPRVSDS ESEDPPRHQA SDSENEEPPK PRISDSESEG PPRHQASDSE NEELPKPRIS
DSESEDPPRN QASDSENEEL PKPRVSDSES EEPQKGPASD SETEDASRHK QKPESDDDSD
GENKGEDTEM QNDSFHSDSH VDRKRIQSSD SEEEEPKRPK IDSDEDEEKV GEEEKVAKRK
AAVLSDSEDE EKASAKKSRV VSDADDSDSD VVSDKSGKRE KTLASDSEEE VGKEELSDKK
NEEKDLFGSD SESGNEEENL IADIFGESGD EEEEEFTGFN QEDLEEEKSE TQVKEAEDSD
SDDNIKRGKH MDFLSDFEMM LQRKKSMSGK RRRNRDGGTF ISDADDVVSA MIVKMNEAAE
EDRQLNNQKK PALKKLTLLP TVVMHLKKQD LKETFIDSGV MSAIKEWLSP LPDRSLPALK
IREELLKILQ ELPSVSQETL KHSGIGRAVM YLYKHPKESR SNKDMAGKLI NEWSRPIFGL
TSNYKGMTRE EREQRDLEQM PQRRRMNSTG GQTPRRDLEK VLTGEEKALR PGDPGFCARA
RVPMPSNKDY VVRPKWNVEM ESSRPGILKK GLSRLEKHKR RFAEQKRLSK VHRAVKFSIE
GNRMPL
//
