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Database: UniProt
Entry: G1M853_AILME
LinkDB: G1M853_AILME
Original site: G1M853_AILME 
ID   G1M853_AILME            Unreviewed;       715 AA.
AC   G1M853;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN   Name=ITGB3 {ECO:0000313|Ensembl:ENSAMEP00000015523.2};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015523.2, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000015523.2, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000015523.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR   AlphaFoldDB; G1M853; -.
DR   STRING; 9646.ENSAMEP00000015523; -.
DR   Ensembl; ENSAMET00000016168.2; ENSAMEP00000015523.2; ENSAMEG00000014704.2.
DR   eggNOG; KOG1226; Eukaryota.
DR   GeneTree; ENSGT01090000259987; -.
DR   HOGENOM; CLU_011772_0_1_1; -.
DR   TreeFam; TF105392; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0043235; C:receptor complex; IEA:UniProt.
DR   GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1240.30; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR040622; I-EGF_1.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR   PANTHER; PTHR10082:SF25; INTEGRIN BETA-3; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   PIRSF; PIRSF002512; Integrin_B; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SMART; SM00423; PSI; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00243; INTEGRIN_BETA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000633};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          16..62
FT                   /note="PSI"
FT                   /evidence="ECO:0000259|SMART:SM00423"
FT   DOMAIN          24..447
FT                   /note="Integrin beta subunit VWA"
FT                   /evidence="ECO:0000259|SMART:SM00187"
FT   DOMAIN          620..704
FT                   /note="Integrin beta subunit tail"
FT                   /evidence="ECO:0000259|SMART:SM01242"
FT   DISULFID        25..35
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        28..61
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        38..50
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        189..196
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        244..285
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        386..398
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        418..667
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        445..449
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        460..472
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        469..507
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        474..483
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        485..498
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        513..518
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        515..548
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        520..533
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        535..540
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        554..559
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        556..587
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        561..570
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        572..579
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        593..598
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        595..643
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        600..610
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        613..616
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        620..629
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT   DISULFID        647..675
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ   SEQUENCE   715 AA;  78763 MW;  AC85FEBC81922A64 CRC64;
     MAQRPLPAES LLVSNICTTR GVRSCQQCLA VSPLCAWCSD EALPLGSPRC NLKENLLKDK
     CAPESIEFPV SEARILEARP LSDKGSGDSS QITQVSPQRI ALRLRPDDSK SFSIQVRQVE
     DYPVDIYYLM DLSYSMKDDL SSIQNLGTKL ALQMHKLTSN LRIGFGAFVD KPVSPYMYLS
     PPEALKNPCY EMKTTCLPMF GYKHVLTLTD QVTRFNEEVK KQSVSRNRDA PEGGFDAIMQ
     ATVCDEKIGW RNDASHLLVF TTDAKTHIAL DGRLAGIVQP NDGQCHIGSD NHYSASTTMD
     YPSLGLMTEK LSQKNINLIF AVTANVVNLY QNYSELIPGT TVGILSTDSS NVLQLIVDAY
     GKIRSKVELE VRDLPEELSL SFNATCLNNE VIPGLKSCVG LKIGDTVSFS IEAKVRGCPQ
     EKEKSFTIKP VGFKDSLTVQ VTFDCDCECQ AQAEPSSHRC NNGNGTFECG VCLCGPGWLG
     SQCECSEEDY RPSQQDQCSP QEGQPACSQR GECLCGQCVC HSSDFGKITG KYCECDDFSC
     VRYKGEMCSG HGQCSCGDCL CDSDWTGYYC NCTTRTDTCM SSNGLLCSGR GKCECGSCVC
     IQPGSYGDTC EKCPTCPDAC TFKKECVECK KFDRGALHED NTCNRYCRDE IESVKELKDT
     GKDAVNCTYK NEDDCVVRFQ YYEDSSGKSI LYVVEEPDWN PLPEVVGNKD GDNLS
//
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