ID G1M853_AILME Unreviewed; 715 AA.
AC G1M853;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB3 {ECO:0000313|Ensembl:ENSAMEP00000015523.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015523.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000015523.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000015523.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; G1M853; -.
DR STRING; 9646.ENSAMEP00000015523; -.
DR Ensembl; ENSAMET00000016168.2; ENSAMEP00000015523.2; ENSAMEG00000014704.2.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_0_1_1; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:UniProt.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF25; INTEGRIN BETA-3; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 16..62
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 24..447
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 620..704
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DISULFID 25..35
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 28..61
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 38..50
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 189..196
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 244..285
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 386..398
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 418..667
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 445..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 460..472
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 469..507
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 474..483
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 485..498
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 515..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 520..533
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 535..540
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 554..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 556..587
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 561..570
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 572..579
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 593..598
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 595..643
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 600..610
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..616
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 620..629
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 647..675
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 715 AA; 78763 MW; AC85FEBC81922A64 CRC64;
MAQRPLPAES LLVSNICTTR GVRSCQQCLA VSPLCAWCSD EALPLGSPRC NLKENLLKDK
CAPESIEFPV SEARILEARP LSDKGSGDSS QITQVSPQRI ALRLRPDDSK SFSIQVRQVE
DYPVDIYYLM DLSYSMKDDL SSIQNLGTKL ALQMHKLTSN LRIGFGAFVD KPVSPYMYLS
PPEALKNPCY EMKTTCLPMF GYKHVLTLTD QVTRFNEEVK KQSVSRNRDA PEGGFDAIMQ
ATVCDEKIGW RNDASHLLVF TTDAKTHIAL DGRLAGIVQP NDGQCHIGSD NHYSASTTMD
YPSLGLMTEK LSQKNINLIF AVTANVVNLY QNYSELIPGT TVGILSTDSS NVLQLIVDAY
GKIRSKVELE VRDLPEELSL SFNATCLNNE VIPGLKSCVG LKIGDTVSFS IEAKVRGCPQ
EKEKSFTIKP VGFKDSLTVQ VTFDCDCECQ AQAEPSSHRC NNGNGTFECG VCLCGPGWLG
SQCECSEEDY RPSQQDQCSP QEGQPACSQR GECLCGQCVC HSSDFGKITG KYCECDDFSC
VRYKGEMCSG HGQCSCGDCL CDSDWTGYYC NCTTRTDTCM SSNGLLCSGR GKCECGSCVC
IQPGSYGDTC EKCPTCPDAC TFKKECVECK KFDRGALHED NTCNRYCRDE IESVKELKDT
GKDAVNCTYK NEDDCVVRFQ YYEDSSGKSI LYVVEEPDWN PLPEVVGNKD GDNLS
//