ID G1M884_AILME Unreviewed; 551 AA.
AC G1M884;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Vacuolar fusion protein MON1 homolog {ECO:0000256|RuleBase:RU367048};
GN Name=MON1B {ECO:0000313|Ensembl:ENSAMEP00000015554.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015554.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000015554.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000015554.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in membrane trafficking through the
CC secretory apparatus. {ECO:0000256|RuleBase:RU367048}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family.
CC {ECO:0000256|ARBA:ARBA00008968, ECO:0000256|RuleBase:RU367048}.
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DR RefSeq; XP_019665635.1; XM_019810076.1.
DR RefSeq; XP_019665636.1; XM_019810077.1.
DR RefSeq; XP_019665637.1; XM_019810078.1.
DR RefSeq; XP_019665638.1; XM_019810079.1.
DR RefSeq; XP_019665639.1; XM_019810080.1.
DR AlphaFoldDB; G1M884; -.
DR STRING; 9646.ENSAMEP00000015554; -.
DR Ensembl; ENSAMET00000016202.2; ENSAMEP00000015554.1; ENSAMEG00000014769.2.
DR GeneID; 100468788; -.
DR KEGG; aml:100468788; -.
DR CTD; 22879; -.
DR eggNOG; KOG0997; Eukaryota.
DR GeneTree; ENSGT00390000006665; -.
DR HOGENOM; CLU_014574_4_1_1; -.
DR InParanoid; G1M884; -.
DR OMA; LEPTDLH; -.
DR OrthoDB; 73361at2759; -.
DR TreeFam; TF314665; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IEA:Ensembl.
DR GO; GO:0019085; P:early viral transcription; IEA:Ensembl.
DR GO; GO:0019086; P:late viral transcription; IEA:Ensembl.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; SAND PROTEIN-RELATED; 1.
DR PANTHER; PTHR13027:SF13; VACUOLAR FUSION PROTEIN MON1 HOMOLOG B; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 111..233
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 278..369
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 410..517
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 59586 MW; 859A4F7DE6E042A8 CRC64;
MEAGGDITAP APGDAEDLED TRFPSEEAGE DGGVHEDPPD SGDGDLEKTE SETKDQPPGL
LSPLPQSEAP SCTCGLWDPA ASENSPMGGP ETGSGGQGGD PSDEDWRSKR KHVFVLSEAG
KPIYSRYGSV EALSTTMGVM TALVSFVQSA GDAIRAIYAE DHKLVFLQQG PLLLVAVSRT
PQSAAQLRGE LLAVHAQIVS TLTRASVARI FARKQNYDLR RLLAGSERTL DRLLDSVERD
PGALLLGAVR CVPLARPLRE ALGALLRRCT APGLALSVLA IGGRLVTAAQ ERTVLAECRL
DPADLQLLLD WVGAPAFAAG EAWAPVCLPR FNPDGFFYAY VARLDAMPVC LLLLGTDPEA
FHDMATCRRL VEEGMHTLGA MRALGEAASF SNAPSAGAPA YSVQAVGAPG LRHFLYKPLD
IPDHHRQLPQ FTSPELEAPY SREEERQRLS DLYHRLHARL HSSSRPLRLI YHVAERETLL
AWVTSKFELY TCLSPLVTKA GAILVVTKLL RWVKKEEDRL FIRYPPKYST PPAAPAASTD
QPSHNGLFTG P
//
