ID G1M8J4_AILME Unreviewed; 822 AA.
AC G1M8J4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Rho GTPase activating protein 42 {ECO:0000313|Ensembl:ENSAMEP00000015664.2};
GN Name=ARHGAP42 {ECO:0000313|Ensembl:ENSAMEP00000015664.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015664.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000015664.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000015664.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1M8J4; -.
DR STRING; 9646.ENSAMEP00000015664; -.
DR Ensembl; ENSAMET00000016316.2; ENSAMEP00000015664.2; ENSAMEG00000014849.2.
DR eggNOG; KOG1451; Eukaryota.
DR GeneTree; ENSGT00940000155492; -.
DR HOGENOM; CLU_011532_1_0_1; -.
DR InParanoid; G1M8J4; -.
DR OrthoDB; 5395569at2759; -.
DR TreeFam; TF316851; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR CDD; cd12066; SH3_GRAF3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 213..322
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 324..520
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 764..822
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 523..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 173..207
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 532..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 92447 MW; AE6ADF366A30DA5B CRC64;
LSMAVQKFSQ SLQDFQFECI GDAETDDEIS IAQSLKEFAR LLIAVEEERR RLIQNANDVL
IAPLEKFRKE QIGAAKDGKK KFDKESEKYY SILDKHLNLS AKKKESHLQE ADTQIDREHQ
NFYEASLEYV FKIQEVQEKK KFEFVEPLLS FLQGLFTFYH EGYELAQEFA PYKQQLQFNL
QNTRNNFEST RQEVERLMQR MKSANQDYRP PSQWTMEGYL YVQEKRPLGF TWIKHYCTYD
KGSKTFTMSV SEMKSSGKMN GLVTGSPEMF KLKSCIRRKT DSIDKRFCFD IEVVERHGII
TLQAFSEANR KLWLEAMDGK EPIYTLPAII SKKEEMYLNE AGFNFVRKCI QAVETRGITI
LGLYRIGGVN SKVQKLMNTT FSPKSPPDID IDIELWDNKT ITSGLKNYLR CLAEPLMTYK
LHKDFIVAVK SDDQNYRVEA VHALVHKLPE KNREMLDILI KHLVKVSLHS QQNLMTVSNL
GVIFGPTLMR AQEETVAAMM NIKFQNIVVE ILIEHYEKIF HTAPDPNIPL PQPQSRSGSR
RTRAICLSTG SRKPRGRYTP CLAEPDSDSY SSSPDSTPMG SIESLSSHSS EQNSTTKSAS
CQPREKSGGI PWIVSPSPSN GQKSLGLWTT SPESSSKEDA TKTDAESDCQ SVASVTSPGD
VSPPIDLVKK GLYGLSGLKR ASASSLTSIS AAEGSKSYSG SIQSLTSVGS KEMPKAPPNP
DLPPKMCRRL RLDTASSNGY QRPGSVVAAK AQLFENVGSL KLVSTGRQAK AMYSCKAEHS
HELSFPQGAI FSNVYPSVEP GWLKATYEGK TGLVPENYVV FL
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