ID G1MAW8_AILME Unreviewed; 1547 AA.
AC G1MAW8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSAMEP00000016492.2};
GN Name=UNC13B {ECO:0000313|Ensembl:ENSAMEP00000016492.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016492.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000016492.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000016492.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMET00000017172.2; ENSAMEP00000016492.2; ENSAMEG00000015550.2.
DR GeneTree; ENSGT00940000154929; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 433..483
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 539..663
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 969..1112
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1219..1361
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1375..1502
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 134..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1547 AA; 175606 MW; DB729757F75D1336 CRC64;
MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL
SVEVWNKGLI WDTMVGTVWI ALKTVRQSDE EGPGEWSTLE AETLMKDDEI CGTKNPTPHK
ILLDTRFELP FAFEDPDSAV DDRDSDYRSE TSNSIPPPYH TTSQPNASVH QFPVPVRLPQ
QLLLQGNSRD SCNDSMQSYD LDYPERRALS PTSSSRYGSS CNVSQGSSQL SEIDQCHEQD
DDHRERDSIH SCHSSGSFSR DGQVGFGEQE KALEVTGEEE KGRACEPKER KEDATIHPPP
DLVLHKDHIL GPQESFPEEN ASSPFTQART HWIRAVTKVR LRLQEIPDDG HPSLPQWLPE
GPAGGLYGID SMPDLRRKKP LPLVSDLSLV QSRKAGISSA MATRTSLKDE ELKSHVYKKT
LQALIYPISC TTPHNFEVWT ATTPTYCYEC EGLLWGIARQ GMRCSECGVK CHEKCQDLLN
ADCLQRAAEK SSKHGAEDRT QNIIMAMKDR MKIRERNKPE IFEVIRDVFT VGKVAHVQQM
KTVKQSVLDG TSKWSAKITI TVVCAQGLQA KDKTGSSDPY VTVQVGKTKK RTKTIFGNLN
PVWEEKFHFE CHNSSDRIKV RVWDEDDDIK SRVKQRLKRE SDDFLGQTII EVRTLSGEMD
VWYNLEKRTD KSAVSGAIRL QISVEIKGEE KVAPYHVQYT CLHENLFHYL TDIQGSGGVL
IPEARGDDAW KVYFDETAQE IVDEFAMRYG IESIYQAMTH FACLSSKYMC PGVPAVMSTL
LANINAYYAH TTASTNVSAS DRFAASNFGK ERFVKLLDQL HNSLRIDLST YRNNFPAGSP
ERLQDLKSTV DLLTSITFFR MKVQELQSPP RASQVVKDCV KACLNSTYEY IFNNCHDLYS
RQYQLKQELP PEEQGPSIRN LDFWPKLITL IVSIIEEDKN SYTLVLNQFP QELNVGKVSA
EVMWQLFAQD MKYALEEHEK DRLCKSADYM NLHFKVKWLH NEYVRDLPAL QGQVPEYPVW
FEQFVLQWLD ENEDVSLEFL RGALERDKKD GFQQTSEHAL FSCSVVDVFT QLNQSFEIIR
KLECPDPNIL AHYMRRFAKT IGKVLMQYAN ILSKSFPDYC TKEKMPCILM NNMQQLRVQL
EKMFEAMGGK ELDPEAADSL KELQVKLNTV LDELSMVFGN SFQVRIDECV RQMADILGQV
RGPGNASPNA RASVAQDADS VLRPLMDFLD GNLTLFATVC EKTVLKRVLK ELWRVVMNTM
ERMIVLPPLT DQTGTQLIFT AAKELSHLSK LKDHMVREET RSLTPKQCAV LDLALDTIKQ
YFHAGGNGLK KTFLEKSPDL QSLRYALSLY TQTTDTLIKT FVRSQTAQGS GVDDPVGEVS
IQVDLFTHPG TGEHKVTVKV VAANDLKWQT AGMFRPFVEV TMVGPHQSDK KRKFTTKSKS
NNWAPKYNET FHFLLGNEEG PEAYELQICV KDYCFAREDR VLGLAVMPLR DVAAKGSCAC
WCPLGRKIHM DETGMTILRI LSQRSNDEVA REFVKLKSES RSIEEGS
//