ID G1ME37_AILME Unreviewed; 992 AA.
AC G1ME37;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSAMEP00000017615.2};
GN Name=GARNL3 {ECO:0000313|Ensembl:ENSAMEP00000017615.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017615.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000017615.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000017615.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1ME37; -.
DR STRING; 9646.ENSAMEP00000017615; -.
DR Ensembl; ENSAMET00000018331.2; ENSAMEP00000017615.2; ENSAMEG00000016676.2.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000159362; -.
DR HOGENOM; CLU_008685_1_0_1; -.
DR OrthoDB; 25782at2759; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 169..385
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 467..777
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 788..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 110494 MW; EF90CFF7839CCAD0 CRC64;
MKSSVSEDLG CRRGDFSRKH YGSVELLISS DADGAIQRAG RFRVENGSSD ENATALPGTW
RRTDVHLENP EYHTRWYFKY FLGQVHQNYI GNDAEKSPFF LSVTLSDQNN QRVPQYRAIL
WRKTGTQKIC LPYSPTKTLS VKSILSAMNL DKFEKGPREI FHPEIQKDLL VLEEQEGSVN
FKFGVLFAKD GQLTDDEMLS NEIGSDAFQK FLNLLGDKIT LKGWTGYRGG LDTKNDTTGI
QSVYTVYQGH EIMFHVSTML PYSKENKQQV ERKRHIGNDI VTIVFQEGEE PSPAFKPSMI
RSHFTHIFAL VRYDQQNDNY RLKIFSEESV PLFGPPLPSP PVFTDHQEFR DFLLVKLING
EKATLETPTF AQKRRRTLDM LIRSLYQDLM PDLHKNMLNR RSFSDVLPES PKSARKKEEA
RQAEFVRIGQ ALKLKSIVRG DAPSSLVASG ICKKEPWEPQ CFCSNFPHEA VCADPWGQAL
LVSTDAGVLL VDDDLPSVPV FDKTLPVKQM HVLETLDLLI LRADKGKDAR LFVFRLSSVH
KAIEGKQAVK SKCDCRDNKL EKTKGCHLYA INTHHSRELR IVVAIRNKLL LITRKHKPGG
VASISLLSPL AESPVEEFQY IREICLSDSP AVMTLVDGPT EESDNLICVA YRHQFDVVNE
STGEAFRLHH VEANRVNFVA AIDVYEDGEA GLLLCYNYSC IYKKVCPFNG GSFLVQPSAS
DFQFCWNQAP YAIVCAFPYL LAFTTDSMEI RLVVNGNLVH TAVVPQLQLV ASRSDIYFTA
TSAVNEVSSG GSSKGASAHN SPQTPPGRDT PVFPSSLGEG ETPSKNLYKI PLRNLVGRSI
ERPLKSPLVS KAVTPPTAIG LGIATIPVTH SLSLSRMEIK EIASRTRREL LGLSDEGGPR
PEGAPKPKSK ARKQLEESQG GPKPGTARST SSDRITTDSL ESPSAPEANP EGRYHSTGSD
QDPVVDREGS PMWGSSPFQL TASSDEDIID LK
//
