ID G1MES5_AILME Unreviewed; 1120 AA.
AC G1MES5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=LOC100476540 {ECO:0000313|Ensembl:ENSAMEP00000017854.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017854.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000017854.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000017854.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; G1MES5; -.
DR STRING; 9646.ENSAMEP00000017854; -.
DR Ensembl; ENSAMET00000018579.2; ENSAMEP00000017854.2; ENSAMEG00000016872.2.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000162702; -.
DR HOGENOM; CLU_001072_1_0_1; -.
DR InParanoid; G1MES5; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005549; F:odorant binding; IEA:Ensembl.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0003031; P:detection of carbon dioxide; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0008355; P:olfactory learning; IEA:Ensembl.
DR GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IEA:Ensembl.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 541..815
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 890..1020
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 834..862
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1120 AA; 121556 MW; 017B04F52766EB37 CRC64;
SQDLQRGLYP EGRCWVLPHG KMCLPSQGPW GTTVSHPRTA FSPPPLSVVL WGALLWAGSL
LDLALGAGTF TLGVLGPWDC DPIFAQALPS VAAQLAVDQA NQDSSLVLGS RLVSAVLPTG
CDTPHALATF LAHKNTVAAF VGPVDPGYCQ AAALLAQSWG KTLFSWACGA PEGGSELVST
LPSAAHVLLS IMRHFGWARV AIVSSHQDIW VATARQVAMT LRTHGLPVGL VTSLGPGKRG
ATEVLEQLCS VDGLKIVVLC MHSALLGGLE QSALLSRAWA RGLADGRLVF LPYDTMLFAL
PYRNHSYPAL GDSGPLQEVY DAVLTISLES GPVDKASEAA RASGEVAMHL EPEQVSPLFG
TIYDAVVLLV HALNRSQSHG AGLSGAHLGD HMGTLNVAGF SQRIQTDEKG RRLAQYVILD
TDGRGSQLVP THILDTGTWR VQSLDRAIHF PGGAPPARDS SCWFDPNMLC VREAQPPGSL
LAFALACLLV LAGGALTCLI RSGIQQRQLV RGPHRVLLTA QELTFIQQPP SRRRLHMDSV
SESKSVVDGG SLRSVAQGSA RSLPAPQEPT NVALYQGEWV WLKRFEAGTA PELRPSCLSL
LRKMRELRHE NVAACLGVFV APGVSAVVLE HCARGSLEDL LRNEALRLDW TFKASLLLDL
IRGMRYLHHR HFPHGRLKSR NCVVDGRFVL KVTDHGYAEL LDVQRAPRPR PAPEELLWTA
PELLRAPRAP GRGTLKADVF SIGIVLQEVL TRGPPYSSSG LSAEEIIRKV VSPPPLCRPL
VSPDHGPPEC IQLMEQCWEE APEDRPSLDQ IYTQFKSINQ GKKTSVADSM LWMLEKYSQN
LEDLIQERTE ELELERQKTE RLLSQMLPPS VAEALKMGAA VEPEYFDQVT IYFSDIVGFT
IISALSEPIE VVGLLNDLYT LFDAVLGSHD VYKVETIGDA YMVASGLPRR NGSRHAAEIA
NMALDILSSV RGFRMKHAPD VPIYIRAGLH SGPCVAGVVG LTMPRYCLFG DTVNTASRME
STGLPYRIHV SRSTVQTLLS LDEGYRIDIR GQTELKGKGV EETYWLVGKA GFPGSLPTPL
DIKPGDPWQD LINQEIRVAF AKARKSMARP GSSGKAFAGS
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