ID G1MFA6_AILME Unreviewed; 800 AA.
AC G1MFA6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Neuronal PAS domain protein 4 {ECO:0000313|Ensembl:ENSAMEP00000018035.1};
GN Name=NPAS4 {ECO:0000313|Ensembl:ENSAMEP00000018035.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018035.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018035.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018035.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002916658.1; XM_002916612.3.
DR AlphaFoldDB; G1MFA6; -.
DR STRING; 9646.ENSAMEP00000018035; -.
DR Ensembl; ENSAMET00000018766.2; ENSAMEP00000018035.1; ENSAMEG00000017065.2.
DR GeneID; 100481488; -.
DR KEGG; aml:100481488; -.
DR CTD; 266743; -.
DR eggNOG; ENOG502QRXX; Eukaryota.
DR GeneTree; ENSGT00530000064165; -.
DR HOGENOM; CLU_013890_0_0_1; -.
DR InParanoid; G1MFA6; -.
DR OMA; KTYFTQE; -.
DR OrthoDB; 614770at2759; -.
DR TreeFam; TF319684; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0071386; P:cellular response to corticosterone stimulus; IEA:Ensembl.
DR GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0060080; P:inhibitory postsynaptic potential; IEA:Ensembl.
DR GO; GO:1904862; P:inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0007614; P:short-term memory; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR CDD; cd19697; bHLH-PAS_NPAS4_PASD10; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF24; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1..53
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 70..144
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 225..271
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 86750 MW; 1A0B095AF1808108 CRC64;
MYRSTKGASK ARRDQINAEI RNLKELLPLA EADKVRLSYL HIMSLACIYT RKGVFFAGGT
PLAGPTGLLS SQELEDIVAA LPGFLLVFTA EGKLLYLSES VSEHLGHSMV DLVAQGDSIY
DIIDPADHLT VRQQLTLPSA LDTDRLFRCR FNTSKSLRRQ SAGNKLVLIR GRFHAHPPGA
YWAGNPVFTA FCAPLEPRPR PGPGPGPASL FLAMFQSRHA KDLALLDISE SVLIYLGFER
SELLCKSWYG LLHPEDLAHA SAQHYRLLAE SGDIQAEMVV RLQAKPGGWA WIYCLLYSEG
PEGPITANNY PISDTEAWSL RQQLNSENTQ AAYVLGTPTM LPSFPENILP QEQCSSPNPL
FTPALGPPRS TNFPSAPELG AASTSEELPQ SQKELGFSYL AFPSGSEPSL QADLSKDLVC
TPPYTPHQPG GCAFLFSLHE PYQTHLSTPS SSLQEQLTPS TATFADQLTP SSATFPDPLT
SPLQGQLTET SARSYEDQLT PCTSAFPDQL LPSTATFPES LGSPAHEQLT PPSTAFQAHL
NSPSQTFPEQ LSPNPTKTYF TQEGCSFLYE KLPPSPSSPG NGDCTLLALA QLRGPLSVDV
PLVPEGLLTP EASPVKQSFF HYSEKEQNEI DRLIQQISQL AQGMDRPFSA EAGTGGLEPL
GGLEPLDSNL SLPGAGPPVL SLDLKPWKCQ ELDFLADPDN IFLEETPVED IFMDLSTPDP
NGEWSSGDPE AAVPGGASSP CNNLSPEDHS FLEDLATYET AFETGVSAFP YDGFTDELHQ
LQSQVQDSFH EDGSGGEPTF
//
