ID G1MFP4_AILME Unreviewed; 570 AA.
AC G1MFP4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN Name=CES3 {ECO:0000313|Ensembl:ENSAMEP00000018174.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018174.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018174.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018174.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR RefSeq; XP_002918450.1; XM_002918404.3.
DR AlphaFoldDB; G1MFP4; -.
DR STRING; 9646.ENSAMEP00000018174; -.
DR ESTHER; ailme-g1mfp4; Carb_B_Chordata.
DR Ensembl; ENSAMET00000018913.2; ENSAMEP00000018174.2; ENSAMEG00000017207.2.
DR GeneID; 100482837; -.
DR KEGG; aml:100482837; -.
DR CTD; 23491; -.
DR eggNOG; KOG1516; Eukaryota.
DR GeneTree; ENSGT00940000155200; -.
DR HOGENOM; CLU_006586_13_0_1; -.
DR InParanoid; G1MFP4; -.
DR TreeFam; TF315470; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00312; Esterase_lipase; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF416; CARBOXYLESTERASE 3; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|RuleBase:RU361235}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT CHAIN 29..570
FT /note="Carboxylic ester hydrolase"
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT /id="PRO_5030003240"
FT DOMAIN 33..546
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
SQ SEQUENCE 570 AA; 62642 MW; 9765704FFC3509EB CRC64;
MGTVVRSGSR VQLWVACLLL AFPATATGSE VTQPEVDTPL GRVRGRQEGV KGTDRLVNVF
LGIPFAQAPL GTGRFSAPRP AQSWEGVRDA STAPAMCLQD LQRMDNSRFV LNGKHRLFPI
SEDCLTLNIY SPAEATAGTR RPVMVWIHGG SLLAGAATSQ DGSALAAYGD VVVVTVQYRL
GFLGFLSTGD EHAPGNWGFL DVVAALRWVQ GNISPFGGDP NSVTISGNSA GSCIVSALVL
SPLAAGLFHR AIAQSGIITM PLILDSNPRV LAQNFADSMG CSSTSSAEML QCLRQITNEE
QILNVKLNTT ASYTIDGTFF PKNPMELLKE RHFNSVPFLV GVNNDEFGWL ILRGWGFLDK
MEQLSLEDIL AMVRPYLASM GVPPEVMPSI IDEYLGSGSN AEAKRNAFQD ILADIMVILP
SLNFSRNLRD SGVPVFFYEF QHRPSSFMKF KPEWVRADHG AEIAFMFGGP FLTDESSLLA
FPEATEEEKP LSLTMMAQWT QFARTGDPNG EGLPPWPPFN QLEQYLEISL TPQVGQKLRE
DRMRFWEETL PVKIEQWQQM RKGRKAQGEL
//
