ID G1MHJ4_AILME Unreviewed; 505 AA.
AC G1MHJ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase kinase 2 {ECO:0000313|Ensembl:ENSAMEP00000018829.2};
GN Name=MAP4K2 {ECO:0000313|Ensembl:ENSAMEP00000018829.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018829.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018829.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018829.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR AlphaFoldDB; G1MHJ4; -.
DR STRING; 9646.ENSAMEP00000018829; -.
DR Ensembl; ENSAMET00000019582.2; ENSAMEP00000018829.2; ENSAMEG00000017815.2.
DR eggNOG; KOG0576; Eukaryota.
DR GeneTree; ENSGT00940000162250; -.
DR HOGENOM; CLU_006347_1_1_1; -.
DR TreeFam; TF105121; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008349; F:MAP kinase kinase kinase kinase activity; IEA:InterPro.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR021160; MAPKKKK.
DR Pfam; PF00780; CNH; 1.
DR PIRSF; PIRSF038172; MAPKKKK; 1.
DR SMART; SM00036; CNH; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 167..478
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 74..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..123
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 55540 MW; C8F80EF3FCDBAC0C CRC64;
LAAPLSPSLA VCLSFSFSFF ASPCLSLTIL LPVPMSFSIR LCWEEEWTLL GKEELSGSLL
QSVEEALEER SLTIRPASEL QDLDSPDDTI GTIKRAPFLG PSPPDQSVPV GTPPPPPPGL
NSPPLLPTAW ATMKHREDPE RSSCHGLPPT PKVHMGACFS KVFNGCPLRI HAAVTWIHPV
TRDQFLVVGA EEGIYTLNLH ELHEDTLEKL ISHRCTWLYC VNNVLLSLSG KSTHIWAHDL
PGLFEQRRLR QQVPLSIPTN RLTQRIIPRR FALSAKIPDT KGCLQCRVVR NPYTGSTFLL
AALPAGLLLL QWYEPLQKFL LLKNFSSPLP SPAGMLEPLV LDGKELPQVC VGAEGPEGPG
CRVLFHVLPL EAGLTPDVLI PPEGLPGTAQ QVIQVDRDTV LVCFDRCVRI VNLLGEPTAT
LAPVLTFDFP IETVVCLQDS VLAFWSHGMQ GRSLDTNEVT QEITDETRIF RVLGAHRDII
LESIPTDNPG AHSNLYILTG HQSSY
//
