ID G1MI36_AILME Unreviewed; 1172 AA.
AC G1MI36;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Laminin subunit beta 3 {ECO:0000313|Ensembl:ENSAMEP00000019021.2};
GN Name=LAMB3 {ECO:0000313|Ensembl:ENSAMEP00000019021.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019021.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000019021.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000019021.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; G1MI36; -.
DR STRING; 9646.ENSAMEP00000019021; -.
DR Ensembl; ENSAMET00000019782.2; ENSAMEP00000019021.2; ENSAMEG00000018004.2.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000160731; -.
DR HOGENOM; CLU_001560_0_0_1; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR CDD; cd22303; cc_LAMB3_C; 1.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF268; LAMININ SUBUNIT BETA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 6.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1172
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030171626"
FT DOMAIN 22..249
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 250..315
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 316..378
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 379..430
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 431..480
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 481..533
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 534..580
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 839..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 949..1091
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 346..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 453..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 483..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 534..546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 536..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1172 AA; 129039 MW; 74B4EB749F0376C1 CRC64;
MRALLLLCFV WPGLLCAQQA CSRGACYPPV GDLLIGRTRF LRASSTCGLT KPETYCTQYG
EWQMKCCKCD SRLPHNYNSH RVENVVSSSG PMRWWQSQND VNPVSLQLDL DKRFQLQDIM
MDFKGPMPAG MLIERSSDFG NTWQVYQYLA ADCTSAFPRV RQGQPQSWQD VRCQSLPQRP
NGHLDGGKVQ LNIMDLASGI PATQSQKIQE LGEITNLRVN FTRLAPVPQR GYYPPSAYYA
VSQLRLQGSC FCHGHADRCA PQPGASASPS ATVQVHDVCV CQHNTAGPNC ERCAPFHSNR
PWRPADDQDP HECQRCDCNG HSESCHFDPA VFAASQGTNG GVCDNCRDHT EGKNCERCQL
HYFRNRRPGA SIQETCIPCE CDPDGAVPGV PCDPVTGQCV CKEHVQGERC DLCKPGFTGL
TYANPQGCHR CDCSLLGSRR DMPCNEESGQ CLCLPHVVGP KCDQCAPYHW KLASGRGCEP
CACDPHNSLG PQCNQFTGQC PCREGFSGLT CSAAAIRQCP DRTYGDAGTT CRACDCDFRG
TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCDLYPVCVA CHPCFQIYDA DFRGQSLRLG
SLRNVTASLR PGLGLDDPGL TSWIADAKSK MEQIQAILSH PLVTEQEVSQ VASAIFSIRQ
TLQGLQPYLP LEEETLSLSE DLKNLDRIFN HLLILYQSKK EQFERISGAN PLGAFRVLTA
AYQRSSQAAQ QVADGSRLLL QFRNSRREAE RLEGQLGGGA GVSSPQLVAL RLEMASLPDL
TPTINKLCGG SRQTACTPGA CPGELCPRDN GTACGPHCRG ALPRAGGAFR MAGQVAQQLQ
GFDAQLQQTR QMIKAAEKAA SKVQSDAQRL ETQVSASRSQ MEEDVRRMRL FIQQVRDFLS
GSDTDAATIQ EVSEAVLALW LPTDSATVLR KMNEIQAIAA RLPNVDLVLS QTKKDIARAQ
RLQMEAEQAR SRAHAVEGQV EDVVGNLRQG AAALQEAQDT MQGTSRSLRL IQERVAEVQQ
VLGPAEGLVA GMTLQLGDFR ARMEELSRRA RQQREQAASA RQLTESAEQR ALSAQEGFER
IKQKYAELKD QLGRSPMLGV QGSRILSVKT EAEELFGETM EMMDRMKDME SELLRGSQAI
KLRSADLTGL EKHVERIRDH INERVLYYAT CK
//
