ID G1MIA3_AILME Unreviewed; 667 AA.
AC G1MIA3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Fermitin family member 3 {ECO:0000313|Ensembl:ENSAMEP00000019088.2};
GN Name=FERMT3 {ECO:0000313|Ensembl:ENSAMEP00000019088.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019088.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000019088.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000019088.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; G1MIA3; -.
DR STRING; 9646.ENSAMEP00000019088; -.
DR Ensembl; ENSAMET00000019849.2; ENSAMEP00000019088.2; ENSAMEG00000018044.2.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR InParanoid; G1MIA3; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17185; FERM_F1_KIND3; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF1; FERMITIN FAMILY HOMOLOG 3; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 354..457
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 667 AA; 75890 MW; 47964FAF0788F211 CRC64;
MAGMKTATGD YIDSSWELRV FVGEDDPEAE SVTLRVTGES HIGGVLLKIV EEIKRKQDWS
DHAIWWEQKR QWLLQTHWTL DKYGLLADAR LFFGPQHRPI ILRLPNRRAL RLRASFSQPL
FQAVAAICRL LSIRHPEELS LLRAPEKKEK KKKEKEPEEE LFDLTKVVLA GGVAPALFRG
MPAHFSDSAQ TEACYHMLSR PQPPPDPLLL QRLPRPSSLL DKTQLHSRWL DSSRCLMQQG
IKAGDMLWLR FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEETDCTEEE MMVFAALQYH
INKLSQSGEA GETTGTDPGL DDLDAALNNL EVKLEGSAST DVLDNLTTIP ELKDHLRIFR
LTLRPRKLTL KGYRQHWVVF KETNLSYYKS QDEAPGDPIQ QLNLKGCEVV PDVNVSGQKF
CIKLLVPSPE GMSEIHLRCQ DENQYAHWMA GCRLASKGRT MADSSYASEV QAILAFLSLQ
RTGGGGSGNH PQGPDASAEG LNPYGLVAPR FQRKFKAKQL TPRILEAHQN VAQLSLSEAQ
LRFIQAWQSL PDFGISYVVV RFKGSRKDEI LGIANNRLIR IDLAVGDVVK TWRFSNMRQW
NVNWDIQQVA IEFHEHINVA FSCVSASCRI VHEYIGGYIF LSTRERARGE ELDEDLFLQL
TGGHEAF
//
