ID G1MJ77_AILME Unreviewed; 1169 AA.
AC G1MJ77;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Protogenin {ECO:0000313|Ensembl:ENSAMEP00000019412.2};
GN Name=PRTG {ECO:0000313|Ensembl:ENSAMEP00000019412.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000019412.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000019412.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000019412.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1MJ77; -.
DR STRING; 9646.ENSAMEP00000019412; -.
DR Ensembl; ENSAMET00000020181.2; ENSAMEP00000019412.2; ENSAMEG00000018373.2.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000155943; -.
DR HOGENOM; CLU_006906_1_0_1; -.
DR TreeFam; TF321506; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF53; BROTHER OF IHOG, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1169
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030171650"
FT TRANSMEM 951..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..222
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 235..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 327..411
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 421..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 517..613
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 618..717
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1109..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 128573 MW; 19485AA912382388 CRC64;
MAPSLRPVAR LRPPGMLLRA LLLLLLLGSG PGVWCFSELF FIKEPQDVTV TRKDPVVLDC
QGHGEVPIKV TWLKNGAKVS ENKRIQVLSN GSLYISEVEG KRGEQSDEGF YQCLAMNKYG
AILSQKAHLT LSTISAFEIQ PVSTEVQEGG VARFACKISS NPPAVITWEL NRTTLPVTMD
RITALPTGVL QIYDVGQRDA GNYRCVAATV AHRRKSMEAS LTVIPATESH SFYTPTIIAG
PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVKLQHAG
VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW
LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS
APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII
DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI
PAKYRRGQVV LYRLSFRLST ENSVQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGPG
ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTVSVKWQQ DAEDTATIQG YKLYYKEEGQ
QENGPIFLDT SDLLYTLSGL DPRRKYHVRL LAYNNIEDGY QADQTVSTPG CVSVRDRMVP
PPPPPHHLYA KANTSSSIFL HWRRPAFTTA QIINYTIRCN PVGLQNASLV LYLQTSETHM
LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW
KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT
CILVCVLILI YRSKARKSSA SKTAQNGTQQ LSRASASLAS GNEAGKNLGG AVDNEDSLMP
MIMPNTFIDA KGGTDLIINS YGPIIKNNSK KKWLFSQDSK KIKVEQPQRR FTQAVCFYQP
GTTVLISDEG SPSSPGQTAS FPRPFGVAAD AEHSANSEGS HETGDSGRFS HESNDDIHLS
SVISTTPLTS SSFTGSDSGN YDICMVWRM
//
