ID G1MPT0_MELGA Unreviewed; 663 AA.
AC G1MPT0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Rho GTPase activating protein 25 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGAP25 {ECO:0000313|Ensembl:ENSMGAP00000000041.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000000041.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000000041.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000000041.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003212426.1; XM_003212378.3.
DR AlphaFoldDB; G1MPT0; -.
DR Ensembl; ENSMGAT00000000670.2; ENSMGAP00000000041.2; ENSMGAG00000000665.3.
DR GeneID; 100551235; -.
DR KEGG; mgp:100551235; -.
DR CTD; 9938; -.
DR GeneTree; ENSGT00950000183015; -.
DR InParanoid; G1MPT0; -.
DR Proteomes; UP000001645; Chromosome 24.
DR Bgee; ENSMGAG00000000665; Expressed in spleen and 15 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13263; PH_RhoGap25-like; 1.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF20; RHO GTPASE-ACTIVATING PROTEIN 25; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 44..150
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 159..353
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 352..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 74720 MW; 2BD3BE29D5AEF0D6 CRC64;
MSLKLPRNWD FNLKMEAAKI ARSRSVMSGE AVTPQPGPPS AMERPLKLGW LKKQRSIVKN
WQQRYFVLRG QQLYYYKDED DTKPQGCLSL QGSTIKEVAS NPEEGGKFIF EIIPGLSGDQ
NRAGQDTCVL MASSQSDMEE WVKSIRRVLG STSGAVFGQR LAETMAYEQK FGQHQVPILV
QKCAEFIREH GVNEEGIFRL PGQDNLVKQL RDAFDAGERP SFGRDTDVHT VASLLKLYLR
ELPEPVVPWM QYEDFLLCGQ TLDVDQKKGH QDLLKQLSLL PRDNYNLLSY ICRFLYEIQL
NSGVNKMSVD NLATVIGVNL IRPKMEDPAT IMRGTLPIQK VMTVMISNHA DLFPPSKDVP
PSPTAQQNDK KTPILRSSVG WDSAEDSTLP RAESSVQRQM KDNPSASCAP GRAVSSRAPS
EDGVQPSKDT LGMWKMQARK RTQTLPNRKS FLTAASPGEK GSNDRNDIFN NDFWKGSTQS
NPRSVLTEGH KRTLSHDLFK LLDLHRASTY DSVPTSHVES SSSSPSPASS CSDKEFQPCP
SPCHQPPEPT SPASSPSEVF QPAPESKESL QNMVLKLQRE MDAQKETYEE QIKSLEKENY
DVWAKVVRLN QDIEREKKKS EELELKLKNM ERLQEDLEKK NKMLEEEIKT IAKSRSKSDA
KTN
//
