ID G1MQ01_MELGA Unreviewed; 220 AA.
AC G1MQ01;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Toll/interleukin-1 receptor domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
DE Short=TIR domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
GN Name=TIRAP {ECO:0000313|Ensembl:ENSMGAP00000000124.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000000124.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000000124.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000000124.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Adapter involved in the TLR2 and TLR4 signaling pathways in
CC the innate immune response. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037750}. Cell
CC membrane {ECO:0000256|PIRNR:PIRNR037750}. Membrane
CC {ECO:0000256|PIRNR:PIRNR037750}.
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DR RefSeq; XP_010721871.1; XM_010723569.1.
DR AlphaFoldDB; G1MQ01; -.
DR Ensembl; ENSMGAT00000000756.3; ENSMGAP00000000124.3; ENSMGAG00000000748.3.
DR GeneID; 100544782; -.
DR CTD; 114609; -.
DR GeneTree; ENSGT00510000048428; -.
DR HOGENOM; CLU_091033_1_0_1; -.
DR Proteomes; UP000001645; Chromosome 26.
DR Bgee; ENSMGAG00000000748; Expressed in proventriculus and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035662; F:Toll-like receptor 4 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045088; P:regulation of innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017279; Tol-interleuk_rcpt_adapt_Tirap.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22662; TIRAP; 1.
DR PANTHER; PTHR22662:SF0; TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037750; TIR_Tirap; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037750};
KW Immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037750};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 75..211
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 220 AA; 24655 MW; BF443E4EC5F7024E CRC64;
MAGWFRRLLQ KPKQSSIHTS SSSHSSTSHS LSSSPSSFSS SASAWSSSSS SSTSTAQPGR
PAPVDISSSS ARWAKSYDVC ICHSEVDLEF VEELVSYLES QPQSLRCFLQ LRDSVAGSAV
MTELCEAVQN SHCWVMLITP SFLQDPWCRY QMHQALAEAP MANGRTIPVL KDIDRKDYPK
ELRNLYYIYT ALKENSFRQI RDTVLRYLEE LCRSSTSGME
//
