ID G1MQA8_MELGA Unreviewed; 312 AA.
AC G1MQA8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
GN Name=GPN2 {ECO:0000313|Ensembl:ENSMGAP00000000253.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000000253.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000000253.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000000253.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR RefSeq; XP_003212520.1; XM_003212472.3.
DR AlphaFoldDB; G1MQA8; -.
DR Ensembl; ENSMGAT00000000887.2; ENSMGAP00000000253.2; ENSMGAG00000000868.2.
DR GeneID; 100539785; -.
DR KEGG; mgp:100539785; -.
DR CTD; 54707; -.
DR GeneTree; ENSGT00950000183172; -.
DR HOGENOM; CLU_037460_0_2_1; -.
DR InParanoid; G1MQA8; -.
DR OMA; ATHNYFL; -.
DR TreeFam; TF300828; -.
DR Proteomes; UP000001645; Chromosome 25.
DR Bgee; ENSMGAG00000000868; Expressed in bursa of Fabricius and 17 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
SQ SEQUENCE 312 AA; 35030 MW; 2CD8EB9BBCBCCBE6 CRC64;
MSESSKGSPL AFGQVVIGPP GSGKTTYCHG MQEFMGRIGR KVAVVNLDPA NEGMPYSCAV
DISELITLSD VMENLKLGPN GGLIYCMEYL EANFDWLQEK LAAFRGHYYL FDCPGQVELY
THHDALKNVF AQLAKWNFRL AAVHLVDSHY CTDPGKFISV LCTSLSTMLH VELPHVNVLS
KMDLIEQYGK LAFNLDYYTE VLDLSYLVDH LASDPFFRNY RRLNAKLVEV IEDYSLVSFV
PLNVQDKDSM RQVMQAVDKA NGCSFGDQEH RSLEALMSAA VGADFHFTST LAVQEKYVQS
QDKTVEEEVM DM
//
