ID G1MRA8_MELGA Unreviewed; 775 AA.
AC G1MRA8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
GN Name=LOC104910743 {ECO:0000313|Ensembl:ENSMGAP00000000699.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000000699.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000000699.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000000699.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR RefSeq; XP_003205395.2; XM_003205347.3.
DR AlphaFoldDB; G1MRA8; -.
DR Ensembl; ENSMGAT00000001344.3; ENSMGAP00000000699.3; ENSMGAG00000001271.3.
DR GeneID; 104910743; -.
DR KEGG; mgp:104910743; -.
DR GeneTree; ENSGT00940000156323; -.
DR HOGENOM; CLU_006000_3_0_1; -.
DR InParanoid; G1MRA8; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000001645; Chromosome 4.
DR Bgee; ENSMGAG00000001271; Expressed in bursa of Fabricius and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 580..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 630..773
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 775 AA; 87999 MW; C6271360F0C0B4F0 CRC64;
MIYIALAAHL PEEQALRQAC LSCDATQSCN CSSMGLDFIP SGLTGKITAL NLAHNRIKLI
RAHDLQQAVN LRALLLQSNQ ISSIDEDSFA SQGKLELLDL SNNSLARLSP AWFGPLFSLQ
HLRIQGNSYS DLGESSPFSS LRNLNSLHLG NPQFSVIRQG NFEGITFLST LKIDGGNLSQ
YEPGSLKSIR KINHMIISVR RIDVFSAVIR DLLHSAIWLE VREIKLDIEN EKLIQNSTLP
STIEKLTFTG ASFTDQYISR IAVLLKEITS LRELEAIDCV LDGKGEWDTT EIARSRQSSV
ETISVTNMTI LDFYLFFDLE GIETQVDKLK RLSIASSKVF MVPCRLARYF SSLLYLDFHD
NLLVNNRLAE TICKGAWPSL QTLNLSKNSL KSLEQAAKYI SNLHKLINLD ISENNFGEIP
DVCGWPENLK YLNLSSTQIP KLTRCIPSTL EVLDVSANNL QDFGLELPLL KELYLTKNHL
KTLPEAAAIP NLVAMSISRN NLNSFSKKEF ASFKQMELLD ASANNFICSC EFLSFIQHEA
GITQVLVGWP ESYICDSPLA VRGAQVGSVS LSLMECHRSF LVSLICILMF LFILVLVVIG
YKYHAVWYMR MTWAWLQAKR KPKRAPTKDI CYDAFVSYSE NDSNWVENIM VQQLEQACPP
FRLCLHKRDF VPGKWIVDNI IDSIEKSHKT LFVLSEHFVQ SEWCKYELDF SHFRLFDENN
DAAILILLEP IQSQAIPKRF CKLRKIMNTK TYLEWPPDEE QQQMFWENLK AALKS
//
