ID G1MVH3_MELGA Unreviewed; 722 AA.
AC G1MVH3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=FAST kinase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00040471};
DE AltName: Full=Protein TBRG4 {ECO:0000256|ARBA:ARBA00043220};
DE AltName: Full=Transforming growth factor beta regulator 4 {ECO:0000256|ARBA:ARBA00042265};
GN Name=TBRG4 {ECO:0000313|Ensembl:ENSMGAP00000002645.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000002645.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000002645.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000002645.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the FAST kinase family.
CC {ECO:0000256|ARBA:ARBA00038281}.
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DR AlphaFoldDB; G1MVH3; -.
DR Ensembl; ENSMGAT00000003326.2; ENSMGAP00000002645.2; ENSMGAG00000002993.2.
DR GeneTree; ENSGT01030000234607; -.
DR HOGENOM; CLU_029448_0_0_1; -.
DR InParanoid; G1MVH3; -.
DR OrthoDB; 5347066at2759; -.
DR TreeFam; TF324885; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000002993; Expressed in heart and 17 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0090615; P:mitochondrial mRNA processing; IEA:Ensembl.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:Ensembl.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR PANTHER; PTHR21228:SF59; FAST KINASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 652..710
FT /note="RAP"
FT /evidence="ECO:0000259|PROSITE:PS51286"
FT REGION 100..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 79774 MW; 30DD57380B21A8B0 CRC64;
MAAPVSREPE VLPLSRSILS VNKGSSANRK WLRCDDVIML RRSACALRLI AGPAVVPRLG
VIGSGFEFSG SCVQARIGVS EGLRPLRRCG FGAASGPGAR PVRLTGRGGP ASPRCSAEPL
RSPPWQPGWC SAAAGGTSSP SPALLLLPRP LCCCPMGSCQ QPEPCHTRLL PPSTPPSPPP
GTQTDSLSKS SNQASLVVTR LSRLAVEKNL ETGDILQDER FQQLTEIVDS QISQVWNNTL
VGLLKSLYSL GMGSSSREMQ SVEHEVLWRL RRLTFRQLAS LAEFLAVKQG KESKLLNEVI
KKLELRWTEL EGTRTVVMLI AKVGHISSVL MDRLEDKALE LAEQFSPEDI RKITLALAYQ
NRRSVPLLRA MSYHLIQKHS ELNLSILMDL IFAYGKLNFH QPQVFQKIAT DLQPHVSAMT
PVEVTRCIRS FALLKWLSLP LFEAISQYAL DNAKQLSIAH LCSIILSFAR LNFQPSGSED
FFNMAHEELQ GQLDSLEPQL LTDLVWSLCV LQQAKPPYLQ HVLAPNFLAA IQGDLSPRAQ
NLRMKLIQIN AAAKLESPEY QGPFLPAGML SAAEPAAEKV TLLQSSLREA LAGVLGSQDN
GRWDVHTIYG WQIDAEVVLN SENKPLPLKD FAAPHLPHSE GTKPLPPGAR RVAFLRWEFP
NFSNRSKELL GRCAMARRHI QAAGFLVVDV PHYEFLELKL ERQRAAYLRD KLHKVVAKEL
AS
//
