ID G1MWJ4_MELGA Unreviewed; 2435 AA.
AC G1MWJ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
GN Name=FN1 {ECO:0000313|Ensembl:ENSMGAP00000003137.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000003137.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000003137.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000003137.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMGAT00000003832.3; ENSMGAP00000003137.3; ENSMGAG00000003306.3.
DR GeneTree; ENSGT00940000155126; -.
DR HOGENOM; CLU_269321_0_0_1; -.
DR TreeFam; TF329915; -.
DR Proteomes; UP000001645; Chromosome 7.
DR Bgee; ENSMGAG00000003306; Expressed in gizzard and 17 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd00061; FN1; 12.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 16.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 16.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 5.
DR PROSITE; PS51091; FN1_2; 11.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 16.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2435
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033026774"
FT DOMAIN 95..135
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 140..183
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 184..227
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 229..273
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 274..318
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 403..451
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 463..511
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 516..559
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 564..606
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 607..650
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 658..751
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 766..855
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 858..949
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 956..1045
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1046..1134
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1136..1222
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1223..1314
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1316..1408
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1409..1496
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1497..1590
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1591..1682
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1683..1770
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1771..1864
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1865..1952
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1953..2044
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2153..2244
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2252..2296
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2297..2339
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2341..2381
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 1439..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2065..2093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 408..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 422..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 468..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 482..509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2435 AA; 268523 MW; 98D160D95EC35815 CRC64;
MPGRGSLRLA LLALCLGAAA XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXLANSVSP
TRVGVRGAAW AGRALPAPSV RRNFAFFPLP PPSAETCFDN GRYYQINQQW ERIYLGNTLV
CTCYGGSRGF NCESKPEPEE TCFDKYTGST YRVGETYERP KDSMIWDCTC IGAGRGRISC
TIANRCHEGG KSYKIGDTWR RPHETGGYLL ECVCLGNGKG EWTCKPLAER CYDNTAGTSY
VVGETWEKPY QGWMMVDCTC LGEGSGRITC TSRNRCNDQD TKTSYRIGDT WSKKDNRGNL
LQCICTGNGR GEWKCERHTS LHTTSTGSGS PSFTNVQTAL YQPQPQQPQP QPHGHCVTDN
GVVYSVGMQW LKTQGSQQML CTCLGNGVSC QEIAVTQTYG GNSDGEPCVL PFTYNGRTFY
SCTTEGRTDG HLWCSTTSNF EQDRRYSFCT EQNVLVQTRG GNSNGALCHF PFLYNNRNYT
DCTSEGRRDN MKWCGTTENY DADQKFGFCP MAAHEEICTT NDGIMYRVGD QWDKQHDMGH
MMRCTCVGNG RGEWTCIAYS QLRDQCIVDG ITYDVNQTFH KRHDEGHMLN CTCFGQGRGR
WKCDPVDQCQ DSETRTFYQI GDSWEKYVHG VRYQCYCYGR GIGEWHCQPL QAYAGATGPV
QVIITESTNQ PNSHPIQWNA PKTSHISKYI LRWRPKNSGR HWKEATIPGH LNSYTISGLK
PGVVYEGQLI SVQQHGPKEV TRFDFTTTST TAVTSNTVSG ETTLLPPMVA TSESVTEITA
SSFVVSWVSA SDTVSGFRVE YELSEEGDEP QYLDLPSTAT SVNIPDLLPG RKYIVNVYQI
SEEGEQNLIL STSQTTAPDA PPEHNVESVD DTSIVISWSR PQAPITGYRI VYTPSVEGSS
TELNLPDTAT SVTLSDLMPG VQYNISIYAV EEHQESTPIF IQQETTGVPR TDEVPSPRDL
QFVEVTDVKV TIMWTPPQSQ VSGYRVEAIP VNRPGQHGQR LPITRSSFAE VVDLLPGTTY
LFKIFAVSQG RESKPLTGEQ TTKLDAPTNL RFINTTEHSV LVLWTRPRAI ISGYRLTAGP
TRGGQPRTYN VGPSATKYLL RNLQPGTEYT VYLVAVKEDL QSARETGVFT TYQPVGSVPP
FNTEVTETSI VITWTPAPRI GFKLGVRPSQ GGEAPREVIS DSGSIVISGL TPGVEYTYSL
TVLMDGQERE TPIIRRVTTP LSPPTNLHLE PNPDTGILIV SWDRSTTPGI SGYRVTTAPT
DGQQGSTLEE VVGADQTSCT FENLNPGVEY NVSVYAVKDD QESIPISKTI TQAVPPPTDL
RFTNVGPDTM RVTWTPPTSI VLSSFLVRYS PVKKEEDVAE LTISPSDNMV VLTNLLPGTE
YLVRVYSVSE QHESAPLSGI QKTGLDSPTG LDFSDITANS FTVHWIAPRA TITGYKIRHH
PEHGVGRPKE DRVPPSRNSI TLTNLLPGTE YVVSIIAING REESVPLVGQ QTTVSDVPRD
LEVNPTSPTS LEISWDAPAV TVRYYRITYG ETGGSSPVQE FTVPGTMSRA TITGLKPGVD
YTITVYAVTG RGDSPASSKP VTVTYKTEID TPSQMQVTDV QDNSISIRWL PSSSPVTGYR
VTAVPKKGHG PTKTKNVPPD QTQVTIEGLQ PTVEYMVSVY AQNQNGESLP LVETAVTNID
RPKGLTFTEV DVDSIKIAWE SPQGQVTRYR VTYSSPEDGI HELLPAPGGE EDTAELHGLR
PGSEYTINIV AIYDDMESLP LTGTQSTAIP PPTNLKFTQV TPTSLTVNWN APNVRLTGYR
VRVNPKEKTG PMKEINLSPD STSAVVSGLM VATKYEVSVY ALKDSLTSRP AQGVVTTLEN
VSPPRRARVT DATETTITIT WRTKTETITG FQIDAIPAAS GQNPIQRTIS PDVRAYTITG
LQPGNDYKIY LYTLNENARS SPVVIDASTA IDAPSNLRFL TTTSNSLLAT WQPPRAKITG
YIIRYEKPGS PAKELQPRPR PGTTEATITG LEPGTEYTIY IIAVKNNQKS EPLVGRKRTD
DLPTLITGPH PNQPDILDVP SVDEGTPYLT NNRYDNGNGI QLPGSSGHPQ TIGHQGQQVF
FEEHGYRRPV PTTATPLRPG SRRQPPNVDE AIEIPGYQVP IIVEPSYPHS RGPRRNDTTG
QEALSQTTIS WRPLLESTEY IISCQPVSQD EDTLQFRVPG TSSSATLTGL TRGATYNIIV
EALKDHRRQK VLEEVVTVGN TVSEGLNQPT DDTCYDTYTG SFYSIGEEWE RLSETGFKLW
CQCLGFGSGH FRCDSSKWCH DNGVNYKIGE KWDRQGENGQ MMSCTCLGNG KGEFKCEPHE
TTCYDDGKMY QVGEQWQKEY FGAICSCTCY GGQQGWRCDN CRRPSVEVAP EGSAGHTYPQ
FTQRYHQATN TNVNCPIECF MPLDVQADTQ HPRGK
//
