ID G1N0M2_MELGA Unreviewed; 1084 AA.
AC G1N0M2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=UBE3C {ECO:0000313|Ensembl:ENSMGAP00000004981.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004981.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000004981.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000004981.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010710695.1; XM_010712393.1.
DR AlphaFoldDB; G1N0M2; -.
DR Ensembl; ENSMGAT00000005706.3; ENSMGAP00000004981.3; ENSMGAG00000005070.3.
DR GeneID; 100547787; -.
DR KEGG; mgp:100547787; -.
DR CTD; 9690; -.
DR GeneTree; ENSGT00940000156321; -.
DR HOGENOM; CLU_002173_2_1_1; -.
DR InParanoid; G1N0M2; -.
DR TreeFam; TF106144; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000005070; Expressed in pectoralis major and 17 other cell types or tissues.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0035519; P:protein K29-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 745..1084
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1052
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1084 AA; 124153 MW; DE8FD99211558784 CRC64;
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFVRGYR
DRNRQYSTQR SEFDRCANLA QTGGTFSTAN GANLTLLVRQ LLFFYKQNED SKRLIWLCQN
LIKQSSQFVK QLDGPDRLIC LFQIKRLLGL CCRLLQNCND DSLNVALPMR MLEVFSSENT
YLPVLQDVSY VTSLIEQILH YMIQKGYYKS LYLLINSKLP SSIEYSDVSR VPLAKILLEN
VLKPLHFTYS SCPEAARQQI FAAFTEEFVA APFTDQIFHF IIPALADVQI VFPYEFFLNA
LLLAENGCSR KSDRAPWLFY FVLTVGETYL GSLSEEGLLV YLRVLQAFLS QLPVSSAGTN
CQDANSDSED EDEEISKMTT TPGDGRISVQ YITEECLKKL DTKQQTNTLL NMVWRDSASE
EVFTLMASIC HTLMVQHRMM VPKVRLLYSL AFNARFLRHL WYLISSMTTR MITGSMVPLL
QVISRGSPMS LEDSSRIIPL FYLFSSLFSH SLISIHDNEF FGDPIEVVGQ RQSSMMPFTL
EELVILSRCL RDACLGIIKL AYPETKPEVR EEYIAAFRSV GVTKNTEMQQ CIQTEQKRWI
QLFKVITNLV KMLKARDTRR NFCPPNHWLS EQENIKADKV TQLYVPSARH VWRVRRMGRI
GPLQSTLDVG LEPAPLSVSE ERQLAILTEL PFVVPFEERV KIFQRLIYAD KQEVQGDGPF
LDGINVTIRR NYIYEDAYDK LSPENEPDLK KRIRVHLLNA HGLDEAGIDG GGIFREFLNE
LLKSGFNPNQ GFFKTTNEGL LYPNPAAQML VGDSYARHYY FLGRMLGKAL YENMLVELPF
ASFFLSKLLG TSADVDIHHL ASLDPEMYKN LLFLKSYEGD VEELGLNFTV VNNDLGEAQV
VELKPGGKDI PVTSANRIAY IHLVADYRLN KQIRQHCLAF RQGLANVVNL EWLRMFDQQE
IQVLISGAQV PISLDDLKSF TNYSGGYAAD HPVIKTFWRV VERFTDEEKR KLLKFVTSCS
RPPLLGFKEL YPAFCIHNGG SDLDRLPTAS TCMNLLKLPE FYDENLMRSK LLYAIECAAG
FELS
//
